Brux is indicated for the short term treatment of peptic ulcer disease in adults where most patients heal within four weeks. Patients with duodenal ulcer disease and H. pylori infection disease that is active for up to one year may benefit from combination therapy that includes Brux with a macrolide antibiotic. Studies show a reduction in recurrence of duodenal ulcers when H. Pylori is treated and a reduced rate of clarithromycin resistance with triple therapy. Resistance should be expected and susceptibility testing performed if patients fail treatment and treatment should be adjusted accordingly. Brux is also indicated for gastric ulcers in adults, and gastroesophageal reflux disease in adults and pediatric populations. Studies have shown the efficacy of Brux for short term treatment in erosive esophagitis. Brux is also indicated for healing erosive esophagitis in both adults and children. Conditions prone to hypersecretion such as Zollinger-Ellison syndrome, multiple endocrine adenomas, and systemic mastocytosis also respond to management with Brux treatment in adults.
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