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Ciclofosfamida (Cyclophosphamide)

Ciclofosfamida is type of drug known as a disease-modifying anti-rheumatic drug (DMARD). It’s used to treat an overactive immune system by targeting cells that cause harm to healthy tissues. It’s an effective treatment for many people who have developed serious complications as a result of their condition.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

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After noting that methotrexate exposure induces prolonged elevations of the glutamate analog homocysteic acid (HCA) within cerebrospinal fluid, we tested whether intrathecal injection of HCA would produce memory deficits similar to those observed after intrathecal methotrexate. Effectiveness of bovine gallstone (Goou) and bear gall powder (Yutan) on chronic liver diseases: a preliminary report. After the framework and tool were subjected to face-validity critique among PFQ investigators, the concept of synergy was added.

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Bodies decompose rapidly here, and there are minimal sources of antemortem data. The treatment of FBSS is challenging and varies from conservative management to reoperation. Further studies are needed to optimise the post-thaw culturing conditions. Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn.

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To investigate emergent literacy skills, including phonological awareness when presented with an initial phoneme-matching task and letter knowledge when presented with a letter-naming task in Thai preschoolers, and to identify key factors associated with those skills. Effects of two truncated forms of human calcitonin-gene related peptide: implications for receptor classification. Platelets and microparticles (MPs) are important for hemostasis and thrombosis, however their participation during AF is not well known.

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Chronic myeloid leukemia 27 years after Thorotrast incorporation However, in the previous 6 months he had noticed unintentional weight loss.

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The bisphosphonate 2-PEBP inhibits cyclosporin A induced high-turnover osteopenia in the rat. AlkB homologues in thermophilic bacteria of the genus Geobacillus HMGA2: a biomarker significantly overexpressed in high-grade ovarian serous carcinoma. Furthermore, micro-Raman results indicate that the a-Si has been crystallized into nanocrystalline Si.

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The FRET efficiency was found significantly reduced within 15 min after intravenous injection, implying that DiIC(18) and DiOC(18) quickly escaped from the circulating micelles. In some instances, EPs yielded abnormalities that were undetected by conventional MR imaging, and the sensitivity increased with the number of EP modalities. Transcranial Doppler sonography as a supplement in the detection of cerebral circulatory arrest. A rigorous diagnostic assessment by a pathologist with close communication with the clinician provides more accurate prognostication and informed treatment decisions.

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Raccoon polyomavirus 1 (RacPyV1) is the suspected cause of an outbreak of fatal brain tumors among raccoons (Procyon lotor) in the western United States. We explored the theoretical underpinnings of a commonly used training strategy by examining issues of training and transfer of skill in the context of a complex video game (Space Fortress, Donchin, 1989). With its unique dose-distribution properties, proton therapy has the potential to improve the therapeutic ratio of prostate radiation by allowing for an increase in dose without a substantial increase in side effects.

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These results encourage us to further study ionic liquids as promising tools for DDS of protein drugs. The objective of this study was to examine the correlation between nutritional status and comprehensive physical performance measures among undernourished older adults who reside in residential institutions. Here, contrary to an expectation based on these studies, we show that two patients with Urbach-Wiethe (UW) disease, a rare condition associated with congenital, complete bilateral amygdala degeneration, exhibit an intact framing effect.

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Just as physically retracting a sessile drop reduces its contact angle with a surface, it was speculated that dissolution could cause contact angles to be reduced. Siderophore biosynthesis a substrate specificity assay for nonribosomal peptide synthetase-independent siderophore synthetases involving trapping of acyl-adenylate intermediates with hydroxylamine. In a randomized, placebo-controlled, double-blind trial, 35 patients with early scleroderma received subcutaneous injections of either IFNalpha (13.5 x 10(6) units per week in divided doses) or indistinguishable placebo. The findings suggest that in a cholera-endemic area, HIV infection is associated with an increased risk for cholera.

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Polycystic kidney disease prevented by transgenic RNA interference. We demonstrate that both relaxation and nondynamical correlation are important for accurately describing shape resonances. To investigate the immunobiology of Rpf domain from Micrococcus luteus. By examining the intracellular localization of green fluorescent protein (GFP) fusion proteins that bind to unique phosphoinositide species, we also demonstrate that phosphatidylinositol-4-phosphate (PI4P), the product of OCRL1, is present at the inclusion membrane.

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Maternal thyroid hormone trajectories during pregnancy and child behavioral problems. Findings support a lower diagnostic cut-off for adolescent BPD, to identify those at-risk at an early stage. Extensive differences in terms of sperm production such as testicular structure and organization, hormonal regulation are reported between humans and insects, yet it is not known to what extent components of the process could be conserved and furthermore to what extent the underlying genetic regulators could be shared from insects to mammals. Accurate experimental data increasingly allow the development of detailed elementary-step mechanisms for complex chemical and biochemical reaction systems. Our findings indicate the need for a careful assessment of (18)F-FDG uptake in patients treated with ARBs.

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We describe a novel design of an inverse ?erenkov accelerator for preinjected relativistic electrons. Male-to-Female Sex Reassignment Surgery Using the Combined Technique Leads to Increased Quality of Life in a Prospective Study. Elevated plasma cardiac troponin T (cTnT) levels in patients with neuromuscular disorders may erroneously lead to the diagnosis of acute myocardial infarction or myocardial injury. Digit span performance was significantly decreased in only the backward direction. Thirteen patients recovering from acute coronary syndrome were interviewed by telephone and seven nurse mentors completed a survey after completing the program.

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The aim of the current study was to investigate the correlations between CDH13 methylation and disease recurrence as well as progression of NMIBC. They were afraid of needle-related procedures and not wakening up after anaesthesia.

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Inhibitory Effects of Antimicrobial Peptides on Lipopolysaccharide-Induced Inflammation. Three patients presenting to the West Roxbury VA Medical Center were identified as having a contractile, focal narrowing in the distal esophagus by upper GI series. Bark pockets included within the trunks of two Japanese cedar trees harvested near Murakami, dating between 1972 and 1982, exhibited lead isotope ratios indicative of Japanese-sourced lead. We apply our method on a time-series RNA-Seq data set of Escherichia coli as it transitions from growth to stationary phase over five hours and investigate the various activity in gene regulation process by taking advantage of the correlation between regulatory gene pairs to examine their activity on a dynamic network. Levels of pyridinoline and deoxypyridinoline in urine, and the level of alkaline phosphatase in serum from patients with bone metastatic prostate cancer were significantly greater than levels in patients with benign prostatic hyperplasia or localized prostate cancer.

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Our results suggest that MUC1 is related to malignant character but MUC5AC alone is related to benign character in IPMTs and that malignant potential of IPMTs expressing MUC2 depends on the degree of MUC2 expression. MnSOD genotype and prostate cancer risk as a function of NAT genotype and smoking status. The two mutants were able to stimulate cellular proliferation, albeit with reduced efficiency when compared with wild-type thioredoxin.(ABSTRACT TRUNCATED AT 250 WORDS)

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Aqueous N-heterocyclization of primary amines and hydrazines with dihalides: microwave-assisted syntheses of N-azacycloalkanes, isoindole, pyrazole, pyrazolidine, and phthalazine derivatives. In warm-blooded vertebrates, neuronal nicotinic acetylcholine receptors (nAChRs) are distinguished from muscle endplate receptors by their ligand affinities and sensitivity to several toxins.

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The aim of the study was to evaluate the incidence, baseline disease characteristics, and disease location based on the Paris classification in pediatric inflammatory bowel disease (IBD) in the Hungarian nationwide inception cohort. One of the most important issues in the development of gas sensors for breath analysis is the fabrication of gas sensor arrays that possess different responses for recognizing patterns for volatile organic compounds (VOCs). Multiple sleep latency test in patients with obstructive snoring Lipopolysaccharide (LPS) caused a concentration-dependent increase of released and cell-associated interleukin-1 (IL-1) in resident peritoneal macrophages from the mouse. This review will discuss the current knowledge of microtubule-based motor proteins (including kinesins and hypothetical dyneins) and will make some hypothesis about their role in the pollen tube.

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A method has been developed to distinguish this family from the rest of the MTB families through real-time DNA amplification and subsequent analysis of the melting point of an amplicon. Testosterone intervention to ameliorate cognitive decline may be warranted only when the efficacy and safety of longer-term use is firmly established. Probable Vogt-Koyanagi-Harada disease with initial unilateral ocular manifestation in a hepatitis C carrier. RBM5 mRNA and protein expression in the A549 and A549/DDP cells was analyzed by semi-quantitative RT-PCR and western blot.

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Aggregates of avidin and lysozyme molecules appeared as features with heights of 1-4nm in the topographic images, consistent with single molecule atomic force microscopy imaging. The proposed SA-IDMS method was applied to several infant formula samples to test its validity. Rationale and Design for the LUME-Colon 1 Study: A Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Nintedanib Plus Best Supportive Care Versus Placebo Plus Best Supportive Care in Patients With Advanced Colorectal Cancer Refractory to Standard Treatment.

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Maternal caloric restriction prior to pregnancy increases the body weight of the second-generation male offspring and shortens their longevity in rats. Diagnostic significance of bleeding time in cardiopulmonary bypass This phenotype was not rescued by exogenously added EGF despite the previously proposed link between Tabby and EGF. Clinical presentations of acute inflammatory adnexae diseases (AIAD) have been delineated in 127 patients who were users of intrauterine contraceptives (IUC).

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Micronutrients and cancer aetiology: the epidemiological evidence. How cytokines maintain the organization of lymphoid tissues during development, in the adult animal, during inflammation and during disease will be discussed in sequence, and the clinical implications of targeting cytokines that regulate lymphoid tissue stroma will be considered.

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Recently, carriers of biallelic mutations in the base excision repair gene MUTYH, have been demonstrated to have a predisposition for multiple adenomas and colorectal cancer. A comparison is presented between the mass, infrared, and (1)H NMR spectra of 235C (2) and a synthetic dehydrohomopumiliotoxin (1), initially proposed incorrectly as the structure for 235C. Ventilation-perfusion mismatch in patients with pleural effusion: effects of thoracentesis. In vivo, p27(kip1) is detected in radial stem cells expressing SOX2 and in newborn neurons of the dentate gyrus. Lymphoproliferative disorders, including follicular lymphoma (FL), multiple myeloma (MM) and chronic lymphatic leukaemia (CLL), are slowly progressive malignancies which remain incurable despite advances in therapy.

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Body size and mortality in women: a 29 year follow up of 12,000 pregnant women in northern Finland. Studies to date have not investigated whether body mass index (BMI) affects the sensitivity and specificity of magnetic resonance cholangiopancreatography (MRCP).

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Propagation modeling to estimate the received waveform was conducted. The present study investigated the effects of CS condensate (CSC) on in vitro wound closure of gingival epithelial cells and their potential interactions with a major periodontal pathogen, Porphyromonas gingivalis. The purpose of this case series is to describe the treatment and outcomes of a series of patients presenting with frozen shoulder syndrome who received a novel chiropractic approach (OTZ Tension Adjustment). A novel association between relaxin receptor polymorphism and hematopoietic stem cell yield after mobilization. Exchange of one of the major bio-elements may have profound evolutionary and geochemical importance.

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The active search for new treatment modalities of established rheumatoid arthritis have created a dynamic period for rheumatology. We observe that the trajectory of the nuclear wave packet in the ground state potential well is strongly affected by the absolute phase of the IR pulse. Overexpression of Ubiquinol-Cytochrome c Reductase Core Protein 1 May Protect H9c2 Cardiac Cells by Binding with Zinc. A decrement-increment was observed at intermediate and high frequencies preceding the onset of clinical signs of IMS.

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When Streptococcus bovis JB1 was repeatedly transferred in a medium that contained the non-metabolizable glucose analog, 2-deoxyglucose, it lost its phosphotransferase system (PTS) for glucose but was still able to take up glucose via a facilitated diffusion mechanism. Estimating free-energy barrier heights for an ultrafast folding protein from calorimetric and kinetic data. A case of Sturge-Weber syndrome (SWS) with gastrointestinal hemorrhage is presented. Little is known about patient characteristics as predictors for outcome in manualized short term psychodynamic psychotherapy (PDT).

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Understanding how people experience the complexities of mental and physical multimorbidity may be crucial to designing and delivering interventions to support successful self-management in this population. Reinnervation of transplanted kemstro classification of drugs pacinian corpuscles by ventral root axons: ultrastructure of the regenerated nerve terminals. This protective effect may occur by affecting the release of a number of gut peptides involved in the control of gastrointestinal motility. Summary estimates of sensitivity, specificity and area under the receiver operating curve (AUROC) were calculated.

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Surgical treatment of knee flexion contracture in patients with myelomeningocele using radical posterior knee capsulectomy leads to improvement in clinical knee flexion contracture, dynamic sagittal kinematics, and walking velocity. The algorithm closely estimates the desired height enhancin medicine hat intraoperatively such that only small intraoperative suture height revisions, if any, are needed. The reviewed studies have demonstrated a higher pain threshold and longer pain tolerance or endurance in five of six studies. The correspondence between the conformational and chromophoric properties of amorphous conjugated polymers in mesoscale condensed systems.

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