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Compazine (Prochlorperazine)
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Prochlorperazine

Compazine is a first-generation antipsychotic, Compazine mainly blocks D2 dopamine receptors in the brain. It can also block histaminergic, cholinergic and noradrenergic receptors. One study also found that Compazine inhibits the P2X7 receptor in human macrophages, but not in mouse cells, preventing a calcium ion influx. This mechanism was independent of dopamine antagonism. Compazine can be administered orally, parenterally, intramuscularly and rectally. All four routes can be given to control nausea and vomiting. For nausea and vomiting pre- and post-surgery, the intramuscular and parenteral routes are both viable options. For psychiatric conditions, the administration can be via both intramuscular and oral routes. For headaches, parenteral is the route used.

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The invitation to present the 2010 Hans Ussing lecture for the Epithelial Transport Group of the American Physiological Society offered me a unique, special, and very surprising opportunity to join in saluting a man whom I met only once, but whose work was the basis, not only for my career, but also for finding the molecular defect in the inherited disease cystic fibrosis (CF). Ab initio potential-energy surfaces for complex, multichannel systems using modified novelty sampling and feedforward neural networks.

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Effects of different forages on the chemical compositions and antiosteoporotic activities of velvet antlers. Sarcoplasmic Reticulum Structure and Functional Properties that Promote Long-Lasting Calcium Sparks.

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Pseudo-sciatica of neoplastic origin: apropos of an unusual case These observations suggest that the circadian expression of BMAL1 mRNA is affected by the CLOCK-induced transcriptional feedback loop in the SCN and peripheral tissues in a different way and that the regulation mechanism appeared to be different from those in mPer2 and DBP expressions in vivo. Assessing support for supervised injection services among community stakeholders in London, Canada. The role of extracellular chitinase in the biocontrol activity of Trichoderma virens was examined using genetically manipulated strains of this fungus. However, the solvent extraction method yields a factor of 3 improvement in detection limits and is less time-consuming than the HMD method.

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