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Kespirona (Spironolactone)

Kespirona is a potassium sparing diuretic like eplerenone that competitively inhibits mineralocorticoid receptors in the distal convoluted tubule to promote sodium and water excretion and potassium retention. Kespirona was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered. It is indicated to treat a number of conditions including heart failure, deem, hyperaldosteronism, adrenal hyperplasia, hypertension, and nephrotic syndrome. Off label uses of Kespirona involving its antiandrogenic activity include hirsutism, female pattern hair loss, and adult acne vulgaris. Kespirona is also frequently used in medical gender transition. Kespirona was developed in 1957, marketed in 1959, and approved by the FDA on January 21, 1960.

Other names for this medication:
Spironolactone, Aldactone, Aldactazide, Aldactazine, Aldazida, Aldazide, Aldozone, Alexan, Alizar, Carpiaton, Espirone, Espironolactona, Expal, Kespirona, Lanx, Letonal, Osiren, Osyrol, Practon, Prilactone, Spiractin, Spiresis, Spirix, Spiroctan, Spirolang, Spirolon, Spiron, Spirono, Spironolacton, Spironolactona, Spironolakton, Spironolattone, Spirotone, Verospiron, Xenalon,

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It was tested both under laboratory conditions and in clinical settings. Fetal Candida infection associated with an intrauterine contraceptive device. Upon examination at the age of 68 years, she showed non-fluent aphasia, word-finding difficulties, circumlocution, frontal release signs, and right-sided bradykinesia, rigidity, and pyramidal signs.

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Nitric oxide (NO) is produced by three distinct isoforms of nitric oxide synthases in the central nervous system. Stark realities: coping with federal and state self-referral paranoia. The molecular structures of silane molecules, which are widely used as adhesion promoters, have been investigated using SFG at buried polymer/silane and polymer/polymer interfaces, providing molecular-level understanding of polymer adhesion promotion. Some new developments and challenges that recent research in imaging informatics will meet are identified and discussed. During a taper of her immunosuppression, she developed grade 1 skin and oral graft versus host disease (GVHD).

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Is genomic imprinting involved in the pathogenesis of pseudotriploid neuroblastoma? The patient refused chemotherapy and five months after surgery, a new lesion was identified in the inguinal region. 85 participants (43 fallers, 42 non-fallers) were evaluated with conventional MRI and diffusion tensor imaging (DTI) sequences of the brain. The highly restricted spatiotemporal expression pattern of apoJ in the developing heart implicates its role in the morphogenesis of the AV canal and outflow tract into cardiac valves.

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A double-blind controlled trial was carried out in 73 hospitalized elderly patients to evaluate the effect of different low doses of the neuroleptic, zuclopenthixol, on behavioural disorders associated with dementia. Tetraspanin microdomains control localized protein kinase C signaling in B cells. Breast carcinoma metastasis to the lacrimal gland: Two case reports. The accuracy of the SMBP is evaluated on three diverse test systems: the intramolecular proton transfer of glycine in water, the hydroxylation reaction in p-hydroxybenzoate hydroxylase, and the spin state energy splittings in the pentacoordinated ferric complex of cytochrome P450cam.

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Broader vaccination of expatriates against HBV infection: do we reach those at highest risk? Bilateral internal thoracic artery grafting (BITA) is associated with improved survival. In vitro, SELENOP levels increased strongly in response to G418, whereas expression of the glutathione peroxidases GPX1 and GPX2 was marginally affected. An increase of the transmembrane pressure was observed in 1 case treated by DFPP but was not observed when using the TFPP or PA method. Delirium among elderly general medical patients in a New Zealand hospital.

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The purpose of this study is to define a computationally efficient virtual test system (VTS) to assess the aggressivity of vehicle front-end designs to pedestrians considering the distribution of pedestrian impact configurations for future vehicle front-end optimization. On the contrary, the sensitivity of lncRNA TRPM2-AS-overexpressed A549 cells to cisplatin decreased obviously when compared with the control. pallidum among pregnant women in Yenagoa, Bayelsa State, South-South Nigeria. In vascular beds, ETA receptors mediate vasoconstriction, whereas ETB receptors mediate vasorelaxation. A proposal for teaching undergraduate chemistry students carbohydrate biochemistry by problem-based learning activities.

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Home parenteral nutrition (HPN) is life-sustaining therapy in some disease states. This occurs with interstimulus intervals of around 1.3, 2.5 and 4.3 ms and could be due to interaction between the responses to each stimulus at either the cortex or spinal cord. Perching but not foraging networks predict the spread of novel foraging skills in starlings. Peroxynitrite-modified H2B induced high titre antibodies as compared to native form which were directly proportional to the nitrotyrosine content. A submucous mass is usually seen in physical examination with an intact mucosa.

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Tumor response, progression-free survival (PFS), overall survival (OS) and adverse events (AEs) were determined. To investigate the role of Asn-242 in P450cin catalysis, it was converted to alanine, and the resultant mutant was characterized. Active SFKs then mediate phosphorylation of Gp140, SFK and PKCdelta with Gp140 acting as a transmembrane scaffold for these kinases. Fluorescence titrations and gel band-shift results indicate that the diphenylfurans bind to RRE and inhibit Rev complex formation in a structure-dependent manner.

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To compare preoperative and postoperative changes in simulated night driving performance after wavefront-guided (wLASIK) and conventional LASIK (cLASIK) for the treatment of moderate myopia. Central zone volume measured from static images optimized for total prostate volume no more closely correlated with lower urinary tract symptom severity or peak urinary flow rates than total prostate volume. To investigate the relationship between serum FT and the clinico-pathological characteristics of prostate cancer in South African patients. On day 40, ER are abundant and often exhibit a whorl-like appearance which is not observed on day 28. Real-time imaging experiments in wild-type and puma-deficient neurons using a fluorescence resonance energy transfer (FRET)-based caspase sensor confirmed the involvement of a second cell death pathway characterized by caspase activation prior to mitochondrial permeabilization and, more prominently, a third, caspase-independent and Puma-independent pathway characterized by rapid cell shrinkage and nuclear condensation.

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Evaluation of the American College of Cardiology Foundation/American Society of Nuclear Cardiology appropriateness criteria for SPECT myocardial perfusion imaging in an Asian tertiary cardiac center. The results of the data analysis revealed similar endocan concentrations in the pericardial fluid of both studied groups.

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The determination of MICs will allow dose scheme selection attending simulation results of this study. As the cancer setting can also be considered one of chronic disease, the rationale for using HSPPCs to treat HIV infection is clear. Normalized time to failure under static loading also agreed well with crack propagation velocity. STOP and GO with NO: nitric oxide as a regulator of cell motility in simple brains. Comparison of different methods to quantify the volume of horse limbs

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Accurate specification of familial relationships is crucial for family-based GWAS, as well as in population-based GWAS with unknown (or unrecognized) family structure. To investigate which retinoid receptors are critical in the regulation by all-trans-retinoic acid (RA) of the mucin genes MUC2, MUC5AC and MUC5B in cultured normal human tracheobronchial epithelial (NHTBE) cells, we used pan-RAR-, pan-RXR- and RAR- isotype (alpha, beta and gamma)-selective agonists and RARalpha- and RARgamma-selective antagonists (RAR is RA receptor and RXR is retinoid X receptor). In the following, we will present and describe the technique of the transsphincteric approach with its variations in rectal surgery in the case of a rare pararectal tumor.

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Friends in higher places: we need to know more about the benefits or otherwise from peer mentoring in nursing curricula. Neugebauer modeling plays an important role in obtaining end-to-end device characterization profiles for halftone color printer calibration.

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Six techniques for the surgical management of fractures of the femur about the tip of the stem of a total hip arthroplasty were evaluated. On-line estimation of the biomass activity during animal-cell cultivations.

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Pica, the ingestion of non-nutritive substances, is considered as an indirect marker of nausea/emesis in non-vomiting species, like the rat. Thus, this is a key point in the use of efficient bit allocation techniques such as rate-distortion algorithms. In a model of severe simulated airway haemorrhage, employing a suction laryngoscope significantly decreased the likelihood of oesophageal intubations in physicians with occasional emergency medical service experience. Recommendation to include fragrance mix 2 and hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral) in the European baseline patch test series.

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The MMC is observed mostly in the stomach and gut of man and numerous animal species. It is not known what pathophysiological variables play a role in the different clinical manifestations of nutcracker syndrome. trachomatis LPS infection induced up-regulation of CFTR expression with enhanced anion secretion, abnormal fluid accumulation in mouse uterus at diestrus, and reduced implantation rate. The eLVT provides additional training of the mLV to bring patients to a DS.

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The Notch signaling pathway plays a substantial role in human NK cell development. HS2 deletion impaired the trimethylation of histone H3 at Lys4 and acetylation of histone H3 at Lys9 and Lys14 in the Il4 locus. Correct algorithms are established to deduce the depolarization for three comparable polarizers calibrated mutually. Elevated extracellular glutamate in the synaptic cleft causes overactivation of glutamate receptors and kills neurons by an excitotoxic mechanism. Stone extraction was attempted initially using conventional techniques.

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The gene for ceruloplasmin-related iron transport protein hephaestin (HEPH) was induced by CDX2 in HT-29 and WiDr. Thirteen right-handed healthy volunteers served as control subjects. Recommendations for the reporting of larynx specimens containing laryngeal neoplasms. In choice tests offering alternating cluster types on an apple branchlet, PCs visited leaf clusters bearing a host apple fruit more than leaf clusters without a fruit. As a stand-alone construct, the I/F Cage yields suboptimal radiographic and clinical outcomes.

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Protein production and secretion in an Aspergillus nidulans mutant impaired in glycosylation. Participants were 23 Dutch dyslexic fourth-graders matched to 23 fourth-grade chronological age controls and 17 second-grade reading age controls. Recent developments in the study of this mycosis are presented in this review. Tracking techniques are vital for the understanding of the biology and ecology of organisms.

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Drosophila melanogaster, an important model organism for studying life science, has contributed more to the research of genetics, developmental biology and biomedicine with the development of genome editing techniques. These analyses, using the ELISA assay, did not detect reductions in GDNF in the ethanol-exposed animals. Intra-operative bleeding, hemoglobin level before and 24 hour after operation, mean arterial blood pressure, heart rate before and after the administration of the drugs, and adverse drug effects. Identification of stable endogenous control genes for transcriptional profiling of photon, proton and carbon-ion irradiated cells. Self-reported data on CU traits, harm-effect moral reasoning in bullying situations, and bullying perpetration were collected from 381 children from 13 schools in Sweden.

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The practitioner should be able to differentiate it from a dentigerous cyst. Treatment is generally started with prednisone, IVIg, or plasma exchange.

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We identified the flavors that e-cigarette users were satisfied with, and we found the users liked e-cigarette cloud production. These patients underwent intraductal biliary RF ablation through the blocked metal stent following external biliary decompression with an internal-external biliary drainage.

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Many patients with Type 1 diabetes estimate their prandial insulin need inappropriately. Rest-redistribution 201-Thallium single photon emission computed tomography predicts myocardial infarction and cardiac death in patients with ischemic left ventricular dysfunction. The impaired clearance occurred despite normal lipoprotein lipase activity and likely reflected feedback inhibition of the lipase by FAs due to their defective removal from the plasma.

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Large resonances of fatty acids in in vivo study appeared to be due to high lipid content of caseous material. Isolated corneal pseudodendrites as the initial manifestation of tyrosinemia type II in monozygotic twins. We use a combination of data from official sources, research studies, case studies of specific innovations, and in-depth knowledge from our own long-term engagement with health sector issues in Bangladesh to lay out a conceptual framework for understanding pluralism and its outcomes. Perivascular treatment with azathioprine reduces neointimal hyperplasia in experimental vein grafts. ORATEL is a 3-year project with the ultimate objective of improving oral health through use of appropriate computerized information systems.

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After Detection: The Improved Accuracy of Lung Cancer Assessment Using Radiologic Computer-aided Diagnosis. Therefore, the study of this process requires the use of a palette of techniques, which are continuously evolving and whose interpretation is not trivial.

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Finger fractures imaging: accuracy of cone-beam computed tomography and multislice computed tomography. Controlled synthesis of kinked ultrathin ZnS nanorods/nanowires triggered by chloride ions: a case study.

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Pore formation was demonstrated by the inhibition of hemolysis with molecules of 2.0 to 2.3 nm in diameter and the release of 86rubidium from erythrocytes without hemoglobin release after exposure to native hemolysin. Time-resolved fluorescence studies on bovine serum albumin denaturation process. Development and Use of Health-Related Technologies in Indigenous Communities: Critical Review. The critical density for cluster formation is estimated using the variational Monte Carlo method.

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Residents who were matched to the anesthesiology program over 9years (graduation classes of 2006 to 2014). Chitosan gelation induced by the in situ formation of gold nanoparticles and its processing into macroporous scaffolds.

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Effectiveness of a web-based physical activity intervention in patients with knee and/or hip osteoarthritis: randomized controlled trial. There was a clear geographical variation in the distribution of the individual risk factors as well as in its clustering with remarkable impact seen in Peninsular Malaysia. QFT is a new method for pediatric tracheotomy that should be performed in younger infants.

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Normal tissue dose and second cancer risk due to megavoltage fan-beam CT, static tomotherapy and helical tomotherapy in breast radiotherapy. Autopsy findings showed marked cerebral swelling with herniation and histological evidence of marked cerebral edema with perivascular protein leakage, indicating blood-brain barrier disruption. The two different antibodies against YBX1 showed discordant immunohistochemical stainings in cell culture and clinical specimens.

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Significant evidence for linkage of schizophrenia to chromosome 19q was observed. Bayesian analysis through programs like BEAST (Drummond and Rumbaut, 2007) and MrBayes (Huelsenbeck et al., 2001) provides a powerful method for reconstruction of evolutionary relationships. It is hypothesized that the combination of a heavier striking vehicle at a taller height results in more intrusion for the struck vehicle and severe injury for the near side occupant. When the multiplicity of infection (MOI, or ratio of infectious virus particles to cells) was fixed, virus yields followed a pattern of progressive decline, with higher MOI driving earlier and faster drops in virus level.

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Experimental validation of numerical simulations on a cerebral aneurysm phantom model. Lactoferrin is a pleiotropic factor with potent antimicrobial and immunomodulatory activities. The nuclear envelope as a mechanostat: a central cog in the machinery of cell and tissue regulation? Individual alpha(M) subunit fused to the enhanced yellow fluorescent protein (eYFP) was imaged at the basal plasma membrane of live Chinese hamster ovary (CHO) cells. We hope that the current success rate can convince people in our locality in cadaveric organ donation so that living donors do not run the risk of dying from the operation, although the risk is estimated to be very small.

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In addition, our results demonstrated that HNPRP hydrogel not only achieved controlled release of growth factors, but also showed strong tissue adhesive ability. For the Ugandan samples, the time from seroconversion was known precisely for a few of the samples and only in one case was less than 2 years.

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In cases of asymptomatic internal carotid-posterior communicating artery (IC-PC) protrusions, it is sometimes difficult to differentiate infundibular dilatation (ID) from aneurysm by digital subtraction angiography. Using precise, in-frame allelic exchange mutagenesis and single-gene complementation, we show sagA, sagB, sagC, sagD, sagE, sagF and sagG are each individually required for SLS production, and that sagE may further serve an immunity function. 3 patients were treated by a covered self expanding nitinol stent. The presence of antigliadin IgA and IgG, anti-tissue transglutaminase IgA by ELISA, and IgA antiendomysium antibody by indirect immunofluorescence microscopy.

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Two tetrasaccharides carrying the trisaccharidic Lewis x motif on a GlcNAc or a Gal residue were produced on the gram-scale by high-cell-density cultures of metabolically engineered Escherichia coli strains that overexpressed the Helicobacter pylori futA gene for alpha-3 fucosyltransferase and the Neisseria meningitidis lgtB gene for beta-4 galactosyltransferase. This study investigated the reliability of the GAF and analyzed certain factors that affect measurement errors when the scale is used by regular psychiatric staff. Conflict laden communication in the team: mobbing--violence toward colleagues

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An earlier generalization, the adaptive fuzzy c-shells (AFCS) algorithm, is examined in detail and is found to have global convergence problems when the shapes to be detected are partial. Pediatric Benign Bone Tumors: What Does the Radiologist Need to Know?: Pediatric Imaging.

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Identification of novel pharmacological activities of an antifungal agent, nystatin, to promote dendritic cell maturation. Summary of new recommendations by the Royal College of Physicians and the Royal College of Pathologists. Expression of lysophosphatidic acid acyltransferase beta (LPAAT-beta) in ovarian carcinoma: correlation with tumour grading and prognosis. Stenting versus endarterectomy and the impact of ultra-early revascularization for emergent admissions of carotid probitor omeprazole capsules side artery stenosis. We discuss the challenges in proving a causal relationship between the presence of a candidate organism and disease.

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Variability and trend of multiple blood lead measures among construction and manufacturing workers. Trends in the specialist workforce in internal medicine in Australia, 1981-1995. According to some positions contrary to abortion, because the embryo is a human animal, there are usually decisive moral reasons not omeprazole capsules enteric coated granules to use them.

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Intraoperative emergence was detected by the elevation of BIS value, HR or MAP. These findings show that there are not only specific olfactory pathways in female moths up to the protocerebral level, but also that integration can begin in the antennal lobe. A Medicare demonstration conducted in 19 counties in three states. The purpose of this study was to analyze the influence of cavity design and restorative material on strain measurement and stress distribution in maxillary premolars under occlusal loading conditions, and correlate these influences with the failure modes analyzed in Part I. Collectively, our findings indicate that viruses employ a more sophisticated strategy to overcome the host metrogyl syrup medicine for dry cough defense response mediated through suppression of RNA silencing during virus infection.

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Despite multiple theories on the pathogenesis of pain in chronic pancreatitis, no uniform and consistently successful treatment strategy exists and abdominal pain still remains the dominating symptom for most patients and a major challenge for clinicians. In both experiments, higher and lower risk perception groups were created using median lyrica vs gabapentin recreational high split of DOSPERT scores. A total of 385 Chinese women and men aged 37-87 years were studied.

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The model may describe the growth of filamentous microorganisms both on a solid medium and in a submerged culture. We describe the use of moxifloxacin-based two-photon (TP)/coherent anti-Stokes Raman scattering (CARS) combined microscopy for differentiating normal mouse brain tissue from metastatic flagystatin suppository indications and contraindications brain tumor tissue based on histoarchitectural and biochemical differences. However, this relationship has not been studied in below average-sized adult patients. Q: Can we reduce the risk of readmission for a patient with an exacerbation of COPD?

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This work has pertinent implications on the design of optimal methods to treat drug resistant bacteria commonly found in swarming colonies. Interferon regulatory factor-1 (IRF-1) is a major immediate early gene induced by prolactin (PRL) in a biphasic, cell cycle-dependent manner in Nb2 T cells. This review summarises the current knowledge about recognition of glycan receptors by rotaviruses. Lastly, the sheer number of entities may be overwhelming, especially, for the diagnosing pathologist, who do not see enough of these on omecip dosage of aspirin a regular basis. Spinal cord injury (SCI) often results in death of spinal neurons and atrophy of muscles which they govern.

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The connection method is employed to verify the availability of points, which avoids that the noisy points are mistakenly regarded as the angular points. Greater confidence in these outcomes may result from pidogrel 75 mg prix de l'arc larger confirmatory studies of longer duration. After preoperative planning and three-dimensional simulation, the osteotomy lines for resection were delineated and the normal anatomic structures for defect reconstruction were ascertained. Adverse effects of pharmacotherapies for attention-deficit hyperactivity disorder: epidemiology, prevention and management. The study finds that the predicted probabilities of fearing immigration enforcement among foreign-born individuals aged 50 and over without citizenship or permanent residence are not negligible.

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Management of typhoid fever in the Department of Medicine at Kathmandu Medical College. A domain-centric analysis of oomycete espirone 25 mg zoloft plant pathogen genomes reveals unique protein organization.

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Fluorescence sensor array for identification of commercial milk samples according to their thermal treatments. To evaluate the validity of cervicovaginal cytology performed at LAPER, the main Laboratory of Pathology of the State of aciklovir stada pharmaceuticals Roraima, Brazil, by interrater agreement (external monitoring) and agreement with histopathologic results. An autosomal dominant form of this disorder was mapped to chromosome 2q33-36, and different missense mutations in exon 1 of the myofibrillogenesis regulator 1 (MR1) gene were identified recently in 2 kindreds.