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Ketovid (Ketoconazole)

Ketovid is active against Candida spp., and Cryptococcus neoformans. However, its activity is limited compared to that of fluconazole and itraconazole. Furthermore, due to its limited penetration to cerebrospinal fluid, it is clinically ineffective in meningeal cryptococcosis. Its activity against the dimorphic moulds, Histoplasma capsulatum, Blastomyces dermatitidis, Coccidioides immitis, Sporothrix schenckii, Paracoccidioides brasiliensis, and Penicillium marneffei is favorable. However, fluconazole and itraconazole are at least as effective as Ketovid against these fungi and are safer. Thus, Ketovid remains as an alternative second-line drug for treatment of infections due to dimorphic fungi. Ketovid is not recommended for treatment of meningeal infections due to Histoplasma capsulatum, Blastomyces dermatitidis, and Coccidioides immitis due to its limited penetration to cerebrospinal fluid. Ketovid is also active against Pseudallescheria boydii and is a good alternative for treatment of pseudallescheriasis. It is also effective in pityriasis versicolor. Ketovid has practically no activity against Aspergillus spp., Fusarium spp., and zygomycetes order of fungi.

Other names for this medication:
Ketoconazole, Nizoral, Akorazol, Arcolan, Arcolane, Asquam, Biogel, Clarazole, Conazol, Daktagold, Daktarin, Dezor, Diazon, Dikoven, Eumicel, Extina, Funginoc, Fungoral, Ilgem, Kenazol, Kenazole, Ketazol, Ketokonazol, Ketolef, Ketovid, Ketozal, Liondox, Lizovag, Micoral, Micosin, Muzoral, Mycoderm, Noell, Orifungal, Oronazol, Panfungol, Perative, Phytoral, Pristinex, Tiniazol, Tinuvin, Xolegel, Yucomy, Zoloral,

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Germline mutations in CDKN2 on chromosome 9p21, which codes for the cyclin D kinase inhibitor p16, and more rarely, mutations in the gene coding for CDK4, the protein to which p16 binds, underlie susceptibility in some melanoma families. Appetite for health-related food taxes: New Zealand stakeholder views. Drug-dependent patients show increased negative mood states such as anxiety and depression that interact with drug craving and quality of life. Exclusive breast feeding in early infancy reduces the risk of inpatient admission for diarrhea and suspected pneumonia in rural Vietnam: a prospective cohort study.

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Even though it does not seem to cause clinical problems, the colonic disease should not be ignored in these patients. Surgically excised masses comprised non-encapsulated proliferations of variably sized arterial- and venous-like vessels, accompanied by clusters of capillaries and immature vascular structures in the feline cutaneous tumour and the canine lingual neoplasm.

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In both EC and HAART recipients, the concentrations of HIV-specific IgG were greater than HIV-specific IgA, but their avidities were comparable, implying that they could compete for antigen. Blood pressure was reduced by felodipine during moderate and maximal exercise and mental stress.

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Calcific specimens from the 8 patients were analyzed by x-ray diffraction, Raman spectroscopy, and infrared spectroscopy. Iodonium salt, diphenyliodonium hexafluorophosphate (DPIHP) serving as a catalyst, was selectively added into the adhesive formulations.

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The gastrointestinal hormone ghrelin reduces energy expenditure and stimulates food intake. Examination of brain specimens revealed vasculopathies with thrombosis of the microcirculatory vessels, pericellular and perivascular edema with multifocal ischemic necrosis, hyperplasia of glial cells, caspase-dependent apoptosis of neurons caused by the cytopathic effect of the virus, and hypercytokinemia. Stable down-regulation of HSP27 in angiogenic tumor cells was followed by long-term tumor dormancy in vivo. HBx has two roles in liver cells, namely pro-apoptotic and anti-apoptotic. For participants with more contact, this lateralized deficit disappeared.

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C-peptide is produced in equal amounts to insulin and is the best measure of endogenous insulin secretion in patients with diabetes. We report the outcome for a consecutive series of chemonaive patients with metastatic or locally advanced neuroendocrine tumours treated with a combination of 5-fluorouracil (500 mg m(-2)), cisplatin (70 mg m(-2)) and streptozocin (1000 mg m(-2)) (FCiSt) administered three weekly for up to six cycles.

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However, the discrete-event model may have arisen from abstraction and simplification of a continuous time system, or through model building from input-output data. The specific residues in these positions can exert influence on the type of solutes that are transported by these proteins. We present CRISPulator, a Monte Carlo method-based computational tool that simulates the impact of screen parameters on the robustness of screen results, thereby enabling users to build intuition and insights that will inform their experimental strategy. Expression of constitutively active Rac1(Q61L) is lethal and results in swollen cells with a large vacuole. However, HR was an independent predictor of subsequent diastolic BP (DBP) regardless of initial BP and other confounders in white men, white women, and black men (0.7 mm Hg increase per 10 bpm).

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Differences and analogies of behavior are discussed focusing, in particular, on the role of hopping in reducing spatially correlated dynamics in the confined system with respect to the bulk. Myeloperoxidase antineutrophil cytoplasmic autoantibody-associated glomerulonephritis in a very elderly patient with generalized vasculitis at autopsy. Cell death was characterized by cytoplasmic vesiculation, peculiar accumulation of glycogen, and dilation of cytoplasmic organelles such as mitochondria and rough endoplasmic reticulum. We report the case of a 56-year-old male with cerebellar lesions mimicking a brain abscess.

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The diagnosis was based on clinical symptoms and/or laboratory and/or imaging results. Cold provocation was initiated by dipping one hand of the patient into cold water of 3 degrees C to 5 degrees C.

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Interest in Translational Research has been growing rapidly in recent years. The histologic features of nafld (steatosis, inflammation, and ballooning) were scored using the nafld activity score, and the degree of fibrosis was determined. Postural activation of the human medial gastrocnemius muscle: are the muscle units spatially localised?

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We found that longitudinal measures of cortical atrophy were widely correlated with sleep quality. Twin-singleton differences in cognitive abilities in a sample of Africans in Nigeria.

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Evaluation includes appropriate radiographs and careful clinical assessment of the soft-tissue envelope. Staphylococcus aureus possesses cell-wall attached proteins that bind the human protein fibronectin (Fn). Eight of the fourteen S100 subfamilies are unique for teleosts, while six are shared with mammalian species and three of those even with cartilaginous fish. Pulse characteristics of a passively mode-locked thulium fiber laser with positive and negative cavity dispersion.

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The purpose of this study was to determine whether Tanshinone IIA (TSA) pretreatment can protect flap tissue against hypoxic injury and improve its viability. We studied 1679 participants in the Secondary Prevention of Small Subcortical Stroke trial with a lacunar infarct visualized on diffusion-weighted imaging.

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These artifacts hamper radiation treatment planning and execution and follow-up imaging. Cost inputs were obtained from the latest Australian representative sources.

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What is the evidence for implantable drug delivery systems for refractory cancer pain? Further characterization of the rat OTB using prototypic pharmacological agents will further determine the extent to which drug effects on rat OTB performance can be generalized to primates. However, H274Y has only been reported in N1 subtypes, which indicates that there must be additional key residues that determine H274Y resistance. Thus, it is evident that the mechanisms associated with commensal microbe facilitation of both pro- and anti-tumor immune responses are context dependent and rely upon a variety of factors present within the tumor microenvironment and systemic periphery. Three keto-carotenoids were prepared by the oxidation of the stable C(40) trisulfone 6, which has been used as the key compound in our beta-carotene synthesis.

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Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray study. Findings from HICs may not apply to LMIC populations, since the meaning and distribution of a given social variable may differ significantly from what is commonly observed in HICs. Sometimes, however, the study group is unknown, for example, motor-vehicle crash victims brought to an emergency department, who may come from far away. Maintenance of adequate oxygen balance to all tissues is one of the primary objectives when dealing with patients undergoing cardiac surgery.

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To analyze influences of the number and location of positive lymph nodes and postoperative radiotherapy on survival for patients with thoracic esophageal squamous cell carcinoma (TE-SCC) treated with radical esophagectomy with three-field lymphadenectomy. Budd-Chiari syndrome is a rare disease, caused by obstruction of the hepatic venous outflow at the level of either the large hepatic veins or (and) the subdiaphragm segment of the inferior vena cava.

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It is important to acknowledge that negative effects on aerobic performance were not observed, thus providing additional support for encouraging the use of this safety device in sports. Pericapillary fibrin cuffs remain a prominent feature, whether they act as a barrier, a marker for endothelial cell damage, or as part of an overall mechanism of macromolecular leakage and trapping. high gestational weight gain (GWG) has been found to be associated with a number of adverse perinatal and long-term outcomes. An efficient optimization algorithm is designed to solve the proposed optimization problem.

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Sodium louroyl sarcosinate (sarkosyl) modulate amyloid fibril formation in hen egg white lysozyme (HEWL) at alkaline pH: a molecular insight study. The interaction between metallic iron pigments (MPs) and the actual constituents of magnetic ink is examined by first determining the adsorption isotherms and analyzing by FTIR the type of bonding that is established between the constituents and MP. In our study, 1612 patients with CS and 1612 age-, sex-, and comorbidities-matched controls were included, and followed up to the end of 2011. We demonstrate that MT-ER is membrane localized in the absence of estradiol (E2), showing punctate membrane and cytoplasmic speckles after E2 exposure.

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However, little is known currently about the histopathological features predicting prognosis, specifically in TSCC. To better understand the relationship between humoral and cellular markers of inflammation and postoperative atrial fibrillation (AF). By means of clinical examples we illustrate the organisation and procedures of this pluridisciplinary consultation which aims to optimize the clinical management of rare genetic diseases. Clinical service delivery has been possible through community engagement and capacity building initiatives directed by community protocols.

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The IgM anti-THP antibody level was higher in the group 1-20 years old than the IgG anti-THP. Interaction of central and peripheral chemoreflexes in neonatal mice: evidence for hypo-addition. In addition, data on the effect of varying oxygen tension on trophoblast production of pro-apoptotic factors and susceptibility of vascular smooth muscle cells to induction of apoptosis are described. Increased ventricular/body weight ratios indicated a significant degree of hypertrophy of LV and smaller hypertrophy of RV.

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External Validation of the Kidney Failure Risk Equation and Re-Calibration with Addition of Ultrasound Parameters. Role of endothelial caveolae in the endocytosis of advanced glycation endproducts (1) The majority of participants personally believed that errors should be disclosed, (2) there was little agreement between participant personal beliefs and perceptions of the norm and practice with respect to which type of errors should be disclosed, (3) there was strong agreement that the erring dentist is responsible for reporting errors, and (4) the attitudes of the participants varied with respect to type of institution, age, gender, and nationality. Oxyntomodulin was the predominant processing product in AtT-20 cells, which contained abundant PC1 mRNA. The aim of this study was to examine the extent and time course of diaphragmatic twitch potentiation and its relationship to both the magnitude and duration of the preceding voluntary diaphragmatic contraction.

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The Web-based Injury Statistics Query and Reporting System (WISQARS) Cost of Injury Reports was used to generate the medical costs accrued by intentional injuries in children. Noninvasive pretherapeutic staging may be supplemented with laparoscopy and laparoscopic ultrasonography (LUS) in order to detect minute liver metastases, carcinosis or other signs of nonresectable or disseminated disease in patients with upper gastrointestinal tract cancer (UGIC). These disorders contrast with those in which antibodies recognize a cell surface antigen and are probably responsible for the disease. The present study reported the case of a 21-year-old male patient, who presented with headaches and dizziness. There may be an association between hepatitis C and type 2 diabetes mellitus as well as thyroid disorders, and sex hormonal preparations may cause specific hepatic lesions.

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We searched PubMed, PsycINFO and the Educational Resources Information Centre database to identify English-language studies published up until 21 November 2016. Patients were measured during their initial evaluation and had neck pain as a primary or secondary complaint. Confirmation that MAT1A p.Ala259Val mutation causes autosomal dominant hypermethioninemia. Sequencing of the CesA genes in a CAA- resistant and -sensitive field isolate revealed five single nucleotide polymorphisms (SNPs) affecting the amino acid structure of the proteins. It has been reported that the oropharyngeal afferent pathway behaves as a first-order factor regulating body fluid.

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In patients with dual AV nodal physiology, simultaneous anterograde fast and slow pathway conduction resulting in an unusual form of nonreentrant AV nodal tachycardia has been observed. This study aimed to determine the median time interval from symptom onset to a confirmed diagnosis and to identify the potential predictors of this interval in Saudi Arabian MERS patients. In antibiotics-treated or germ-free mice, tumor-infiltrating myeloid-derived cells responded poorly to therapy, resulting in lower cytokine production and tumor necrosis after CpG-oligonucleotide treatment and deficient production of reactive oxygen species and cytotoxicity after chemotherapy. The IOP change was dependent on the initial IOP reading and initial HR. Clearer role descriptions for all groups of nursing staff are recommended as well as general competence development in geriatric nursing care.

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Desynchronosis altered chromatin structure in immune system cells and suppressed the immune response. This includes a brief history of antipsychotic use in America, acute treatment and chronic maintenance with antipsychotic drugs, the recent advent of atypical antipsychotic agents, and management of antipsychotic-induced side-effects. Further characterization of the effect of this mutation could help identify the function of the PS1 protein and the pathogenic mechanisms of AD. Historically, varicella has been a disease predominantly affecting preschool and school-aged children in the United States. We examined the effect of phenotypes including hair-pulling severity and depressive symptoms on absolute and relative stability of affective regulation over time, using multiple linear and hierarchical regression analyses.

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During the DRINKADRIA project, a common methodological framework has been developed, for efficient and effective cross-border water supply and resources management, taking into consideration different resources types (surface and groundwater) emphasizing in drinking water supply intake. Ultrastructural study of a perineurioma with ribosome-lamella complexes. In Alzheimer disease there was a significant increase of the latency of the P55, N65, P100, and N130 components, as well as an increase of the P55-P100 interpeak latency, compared with matched normals. Impact of maternal metabolic abnormalities in pregnancy on human milk and subsequent infant metabolic development: methodology and design. The pattern of continuous secretion into lumina detected for total protein in the absence of stimulation, suggests that other secretory proteins may also be secreted similarly but at different rates.

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L-selectin is a cell adhesion molecule that plays an important role both in mediating the initial capture and subsequent rolling of leukocytes along the endothelial cells and in the signal transduction for leukocyte activation. If, however, the decision is made to perform them, magnetic resonance imaging should be a method of choice. Outcome analysis of penile implant surgery after external beam radiation for prostate cancer. The distribution of amphotericin B in lung tissue was studied in 18 patients with primary or secondary lung cancer who underwent thoracotomy and pulmonary resection.

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Cohort study including all non-psychotic subjects who were assessed on suspicion of psychosis risk by the OASIS UHR service in the period 2001 to 2015. These results suggest that the HDAC8 protein is degraded via autophagy and the ubiquitin-proteasome system and that cAMP signaling increases HDAC8 protein levels by reducing JNK-mediated autophagy and ubiquitin-proteasome-dependent degradation of the HDAC8 protein in H1299 lung cancer cells. This is a retrospective study of available Ministry of Health surveillance data and programme reports, mostly from 2003 to 2015.

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The fluorescence lifetime of bound and free NADH was calculated from biexponential fitting of the fluorescence intensity decay within different spectral regions. Anaerobic metabolism occurs in the substratum of gonococcal biofilms and may be sustained in part by nitric oxide.

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We investigated the prevalence of CKD and its early markers in Kumbotso, a rural community in northern Nigeria. Nomenclature and definition in asymmetric regional body overgrowth. The tropharium of the common shorebug Saldula saltatoria consists of 2 zones: the apical mitotic region and the distal one comprising numerous mononucleate nurse cells.

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To evaluate the efficiency and safety of outpatient physical exercises (PE), calculated using ergospirometry (ESM) in patients in the early periods after elective percutaneous coronary interventions (PCI) during incomplete coronary bed revascularization. In experimental animals with tumors it was studied antitumor activity of spirocyclic hydroxamic acids which could be classified as targeted agents as their target was enzyme histonedeacetylase, which was involved in the neoplastic process.

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Tigecycline pharmacokinetics, tolerability, safety, and effect on intestinal microflora in healthy Japanese male subjects. We aimed to confirm their pharmacological profiles focusing on tissue macrophages.

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Previous studies suggested a role for circulating Tfh cells (cTfh) following influenza vaccination in adults, but cTfh have not been studied in elderly adults in whom weak vaccine responses are often observed. Despite targeted antibiotics and anti-fungi therapy, the lesion extended for as long as 18 months and only massive granulocytes pockets transfusions in association with G-CSF had the capacity to cure this lesion. A dynamically adjusted mixed emphasis method for building boosting ensembles.

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These results suggest that endothelin is secreted by a constitutive pathway and that the lysosome may play an important role in regulating the biological activity of endothelin. Research on total arsenic absorption of Tetrahymena pyriformis exposed to arsanilic acid feed additive and its environmental degradation products by HG-AFS While the role of HSB patterns has been investigated in comparative anatomical studies, until recently there has been little consideration of HSB patterns in human teeth. The difference in ERG measurements was not statistically significant between the control or treatment eyes. Preparation and reactions of myoglobin mutants bearing both proximal cysteine ligand and hydrophobic distal cavity: protein models for the active site of P-450.

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Dihydroergotamine (DHE) use during gestation and the risk of adverse pregnancy outcomes. Individual secretory vesicles (approximately 50 nm diameter) were resolved with the AFM when imaged either dry or in solution. Peroxisome proliferator-activated receptor-gamma is a new therapeutic target in sepsis and inflammation.

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Partnerships for preventing violence: a locally-led satellite training model. Levels of agreement between adolescents and mothers about residing in a two-biological-parent family, single-mother family, or married stepfamily were considerably higher. The management of the pain, the fever and the neutropenia is important.

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The lipid abnormalities and levotac medicine for diarrhea the reduction in plasma PAF-AH activity were significantly correlated with plasma C-reactive protein levels and were not observed in patients with inactive JRA. They remained symptoms free for 7 and 10 months after Wallstent implantation until death. These unintended consequences can lead to medical noncompliance in misguided efforts to retain satisfactory sexual activity, and thereby worsen cardiovascular problems. Electroanatomical voltage mapping is able to identify RVOT tachycardia due to concealed ARVC/D by detecting RVOT electroanatomical scars that correlate with fibrofatty myocardial replacement at EMB and predispose to sudden arrhythmic death. Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish.

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HRQOL measures were compared to selected chronic conditions and risk factors. After GH therapy had been started, we observed two relapses of previously completely excised pilomatricoma in the same location and a new pilomatricoma formation on the chin. OK-432, a streptococcal preparation, has been shown as an effective activator to induce human monocyte-derived dendritic cells maturation. The effects of proteinuria on urinary cystatin-C and glomerular filtration rate calculated by serum cystatin-C. In addition, soil microbial communities suppressed the expression omesec omeprazole 20mg capsule of marker genes involved in nitrogen uptake, oxidative stress/redox signaling, and salicylic acid (SA)-mediated plant defense while upregulating jasmonate (JA) signaling, cell wall organization/biosynthesis and photosynthesis.

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Population surveillance sites, such as those operated within the INDEPTH Network, have the potential to contribute to bridging the information gaps. Endoscopic thyroidectomy (ET) or robotic thyroidectomy is yet to be applied to thyroid carcinoma lansoloc 30mg price invasive to the trachea and to wide lymph node node metastasis.

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These genes are constitutively expressed at MG fruit stage in two different tomato genotypes as well as in their ripening mutants, including rin, nor and Nr, sildenafil buy generic and an ethylene-deficient transgenic line, ACS2-antisense. The list of comorbidities associated with hidradenitis suppurativa (HS) is extensive, although these diseases do not necessarily share a common causality. A novel technique for cheek mucosa defect reconstruction using a pedicled buccal fat pad and buccinator myomucosal island flap.

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Two cases of typical painful tic convulsive are described, showing representative slices of magnetic resonance imaging corresponding to the aetiology of each case, as well as a description of the surgical technique employed in our institution. Sleeve lobectomy for selected cases of intratracheal tumor has better parenchyma preservation compared to pneumonectomy. This is their first implementation pehatrim forte adalah obat untuk diabetes to evaluate quality in headache care as a multicentre national study.

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However, heparin-bound PCI, which was able to nufloxib side effects form complexes with 125I-urokinase, did not form complexes with 125I-tissue-kallikrein. prospective observational study of probable and confirmed cases of influenza A (H1N1)/2009 infection concerning hospitalized patients in a polyvalent intensive care unit (ICU). The aim of the present study was to observe the effect of ultrasound (US) on estradiol level, bone mineral density (BMD), bone biomechanics and matrix metalloproteinase-13 (MMP-13) expression in ovariectomized (OVX) rabbits.