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Narutis (Clopidogrel)
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Clopidogrel

Narutis is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke. Narutis is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease. It has been shown to be superior to aspirin in reducing cardiovascular outcomes in patients with cardiovascular disease and provides additional benefit to patients with acute coronary syndromes already taking aspirin. Narutis was granted FDA approval on 17 November 1997.

Other names for this medication:
Clopidogrel, Plavix, Anclog, Anlet, Antiplar, Artevil, Clavix, Clopicard, Clopilet, Clopivas, Deplatt, Diloxol, Duoplavin, Expansia, Farcet, Globel, Grepid, Iscover, Karum, Klopidogrel, Nabratin, Narutis, Nefazan, Noklot, Pidocar, Pidogrel, Pladex, Plagerine, Planor, Tisten, Troken, Trombex, Vaclo, Zyllt,

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MTHFR C677T polymorphism in chronic pancreatitis and pancreatic adenocarcinoma. To overcome the enzymatic and permeation barrier, protease inhibitors and permeation enhancers were also added. To test this hypothesis, we applied a quantitative, allelic-specific, real-time PCR method to survey the levels of AI in BRCA1/2 in lymphoblastoid cell lines (LCL) from 126 familial ovarian cancer patients who are noncarriers of any known BRCA1/2 and MLH/MSH mutations and 118 cancer-free relative controls. We present the cytogenetic analysis of 23 cases of polyploid colorectal adenocarcinomas. The relationship of this drug to the earlier development of chlorpromazine is explored to clarify the imperatives of drug classification in modern psychiatry.

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To evaluate the efficacy and safety of direct oral anticoagulant (DOAC) therapy in hospitalized patients with suspected heparin-induced thrombocytopenia (HIT). Loperamide is a piperidine analogue, acting as agonist on peripheral opioid receptors, exhibiting affinity and selectivity for the cloned mu human opioid receptor compared with the delta human opioid receptor.

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Effects of partial volume and phase shift between fat and water in gradient-echo magnetic resonance-mammography. To analyze drug prescriptions for insulin and oral antidiabetic drugs in type 1 and type 2 diabetes mellitus patients seen in the Brazilian Public Healthcare System (Unified Health System - SUS) in Ribeirao Preto, SP, Brazil. The clinical and pathological characteristics of this case were presented, and the literatures were reviewed.

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Significant inhibitors of human P450 isozymes 1A2, 2C9, 2C19, 2D6, and 3A4 were then selected for examination of their structural features by molecular docking to determine their molecular interaction with several P450 isozymes. Most of the neurodegenerative disorders seem to be multifactorial and cannot be traced back to one single cause.

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Willingness to undergo colorectal cancer screening in first-degree relatives of hospitalized patients with colorectal cancer. The following optic nerve parameters were evaluated: disk area, cup/disk area ratio, cup shape, height in contour, rim area, rim volume, maximum cup depth, cup area, cup volume, retinal height, and retinal cross-section area. To develop a simple and rapid tissue procurement protocol for use in obtaining a homogeneous epithelial cell population from clinical tissue and the recovery of nucleic acids and proteins of high quality and quantity. Also, kappa values were computed between the DSM-III-R and DSM-IV versions of these disorders as an index of coverage or agreement across the two systems.

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We have established a hepatocarcinoma cell line (LFCI2 A) that produces voluminous tumors when injected subcutaneously into syngeneic Commentry rats. The essential trust placed in the surgeon by her patients has been weakened by changes in the structure and financing of the health care system. Actin, a key cellular component, has an established role as a cellular sensor, with reorganization and alterations in actin dynamics being a well known consequence of signalling. The search continues for a highly valid marker for estimating visceral adiposity that is a simple and low cost tool able to screen individuals who are highly at risk of being viscerally obese.

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Systemic superoxide anion, protein carbonyls, and nitrotyrosine above specific cut-off values best identified underlying COPD among all patients. Breaking bad news in assisted reproductive technology: a proposal for guidelines. We compared 3-year death rates of four consecutive nationally representative samples (1997-1998, 1999-2000, 2001-2002, and 2003-2004) of U.S.

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Circulating fibroblast growth factor 21 in patients with liver cirrhosis. Included in the hypertension syndrome are abnormalities of lipid profile, insulin resistance, changes in renal function, left ventricular hypertrophy and reduced arterial compliance.

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Computed tomography confirmed ovariectomy-induced loss of bone in the proximal tibial metaphysis compared with the sham group. Primary lesions associated with metastatic vaginal adenocarcinoma are most often the uterus, and are very rarely from the colon or rectum.

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Empirical and mechanism-based QSPKR models are discussed, including specific examples for oral absorption, nonspecific protein binding, volume of distribution, total metabolic stability and specific interactions with drug metabolizing enzymes. These results hold promises to better understand the impact of age on tumor progression processes while highlighting new markers of the tumor cell invasion front. As a sub-study of the Australian Work Exposures Study, this study investigated the prevalence of occupational exposure in Australian RTWs.

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These strategies including ischemic preconditioning, remote ischemic preconditioning as well as the acute phase of streptozotocin-induced diabetes mellitus, provide a similar effect of protection. Vitellogenesis in the cestode Atractolytocestus huronensis Anthony, 1958 (Caryophyllidea: Lytocestidae). However, the absolute increase in 3-year risk of lung cancer for every 10 additional pack-years smoked was less for women than men, 13.6 versus 52.9 per 100,000 persons.

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Expression of a heterologous xylose transporter in a Saccharomyces cerevisiae strain engineered to utilize xylose improves aerobic xylose consumption. The purpose of this article is to outline the risk of cardiac adverse events (AEs) from 5-HT3-RAs, with focus on the three most commonly used, ondansetron, granisetron and palonosetron. Blood samples for cytogenetic analysis were obtained from 23 animals closely related to a pedigree British Friesian bull which was heterozygous for a Robertsonian translocation, and from 35 of its daughters. Nursing homes should strive to develop diverse and meaningful activity programs for residents in order to occupy their time and provide them with a greater sense of purpose. The placental vascular endothelial growth factor polymorphisms and preeclampsia/preeclampsia severity.

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Survivors of childhood cancer practiced several suboptimal health behaviors. All studies used Markov models with annual cycles to represent the long-term clinical pathway.

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MAS064D appears to be an effective and well tolerated cream for the treatment of mild to moderate SD of the face. Thai people living with tuberculosis and how they adhere to treatment: A grounded theory study. Primary squamous cell carcinoma of the liver arising from a complex liver cyst: report of a case. A total of 253 samples of pleural and peritoneal fluid were studied by May-Gruenwald-Giemsa (MGG) stain and Papanicolaou (Pap) staining. Although combined treatment with moclobemide and selegiline was well tolerated, the supra-additive potentiation of the tyramine pressor effects means that dietary restriction of tyramine intake will be necessary during such combination therapy.

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In contrast, standard doses of lopinavir/ritonavir in the third trimester showed markedly decreased exposure, and higher doses of this co-formulated agent should be given to women during the third trimester. According to the results of the present study, the plant crude extracts could be used as medicine for the treatment of different diseases.

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Endothelial dysfunction is a fundamental step in the atherosclerotic disease process. The objectives of this study are to evaluate the effects of maternal acupuncture treatment on lung maturation in preterm rats. Impact of acute COPD exacerbation and repetitive episodes on the disease evolution A comparison of serum CYFRA 21-1 and SCC Ag in the diagnosis of squamous cell lung carcinoma. Therapeutic effect of artemisinin on lupus nephritis mice and its mechanisms.

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In conclusion, DAS increased the production of ROS, caused cell cycle arrest, decreased cell proliferation and induced apoptosis in Colo 320 DM cells. Isothermal titration microcalorimetry results show that the driving forces for fiber formation are electrostatic and hydrophobic interactions, as well as the release of counterions and bound water molecules. The expression of Hsp70 exhibited different spatial patterns among nuclear, membrane and cytoplasm in 507 NPC tumor tissues. Characterization of diadzein-hemoglobin binding using optical spectroscopy and molecular dynamics simulations. Clostridium spp., Bacteroides spp., Fusobacterium spp., anaerobic cocci and others was demonstrated.

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