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In 47 consecutive non-selected patients (50 hips), the clinical and radiographic results of cementless total hip arthroplasty using a collum femoris preserving stem, a pressfit cup and an alumina-polyethylene pairing were prospectively evaluated. Efficacies of mefloquine alone and of artesunate followed by mefloquine, for the treatment of uncomplicated, Plasmodium falciparum malaria in eastern Sudan. A treatment for impulse control disorders and paraphilia: a case report. The well-established relationship between depression and memory complaints may exist in some community-dwelling older adult populations only on account of the manner in which both are associated with neuroticism. An unusual thionation strategy of mesoionic compounds with aryl isothiocyanates enables a facile synthesis of 1,3-thiazolium-4-thiolate systems.

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Biocompatibility of heparin-coated membrane oxygenator during cardiopulmonary bypass. The myocardium was studied by light microscopy for fresh necroses. Based on this measure, the heterogeneous networks demonstrated thicker fingering patterns than the homogeneous networks.

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MECHANISMS IN ENDOCRINOLOGY: Towards the clinical translation of stem cell therapy for type 1 diabetes. Missense mutations in the low-affinity, fast-channel syndrome and in a disorder associated with mode-switching kinetics of AChR result in brief activation episodes and reduce the probability of channel opening. Two of the polymers were graft copolymers, having backbones consisting of poly(methyl methacrylate-co-ethylhexyl acrylate) and poly(styrene-co-acrylamide), respectively, and poly(ethylene oxide) PEO 2000 grafts. The aims of the thesis were to investigate i) the prevalence of reduced salivary flow rate in different age groups of adults, ii) the relationship between reduced salivary flow rate, general health and dental caries, iii) the influence of time of measurement on reduced salivary flow rate, and iv) if reduced salivary flow rates could be increased by iron supplementation. Chiral capillary electrophoretic analysis of verapamil metabolism by cytochrome P450 3A4.

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pyogenes M1T1 strain 5448 revealed that HKU16 displays increased adherence to HEp-2 human epithelial cells, whereas HKU16, HKU30, and 5448 exhibit equivalent resistance to neutrophils and virulence in a humanized plasminogen murine model. Role of anti-nucleosome antibody in the diagnosis of juvenile systemic lupus erythematosus In phoebes, a specialized forebrain region in the intermediate arcopallium seems homologous to the oscine song nucleus RA (robust nucleus of arcopallium) by its neural connections, expression of glutamate receptors and singing-dependent immediate-early gene expression.

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Silymarin improves the behavioural, biochemical and histoarchitecture alterations in focal ischemic rats: a comparative evaluation with piracetam and protocatachuic acid. Apolipoprotein E is a transport protein, which by binding to lipids forms a lipoprotein particle. Aphid bioassays indicated thatRhopalosiphum padi andSchizaphis graminum did not survive on grasses containing loline alkaloids and thatS. Use of fMRI to guide decision-making in a clinical stroke trial is feasible. Saturation transfer double-difference NMR spectroscopy using a dual solenoid microcoil difference probe.

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To assess the relevance of amidation also in other decapods and how much the differences in the cHH amino acid sequence can affect the functionality of the peptides, we carried out heterologous bioassays on the cambarid Procambarus clarkii and palaemonid Palaemon elegans. The purpose of this study was to evaluate the influence of post-coronary artery disease (CAD) depression diagnosis on heart failure (HF) incidence. RET high-resolution amplicon melting analysis is a sensitive, closed-tube assay that can detect RET protooncogene sequence variations. Sexuality education in a representative sample of Portuguese schools: examining the impact of legislation. Furthermore, the impact of age, family socio-economic status, educational level of the parents, language region and civil status was analysed.

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Induction of cytotoxic T-lymphocytes and antitumor activity by a liposomal lipopeptide vaccine. The high affinity of monobody AS25 was designed to target the Src homology 2 (SH2) domain of Bcr-Abl, leading to allosteric inhibition of Bcr-Abl through formation of protein-protein interactions. Laparoscopic hysterectomy in the presence of previous caesarean section: a review of one hundred forty-one cases in the Sydney West Advanced Pelvic Surgery Unit. Twenty-two myopic patients undergoing uneventful LASIK were enrolled in this study. This antibiotic was delivered at different dosage, alone or in association with Fans.

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Substantial long-term complications of asymptomatic bacteriuria in the elderly have not been identified and there is no convincing evidence that asymptotic bacteriuria is associated with impaired survival. All participants were evaluated for the presence of psoriasis and inflammatory arthritis. Pulmonary embolism (PE) is a common cardiovascular disease that can be easily missed or misdiagnosed. As expected, SMILE repressed androgen-dependent growth of LNCaP and C4-2 cells. We conducted a phase I and II trial of a modified version of ECF, utilizing 5-FU as a 24-h infusion on day 1 and day 8 of a 21-day cycle, administered with sodium folinate as a modulator of 5-FU (ECSF).

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To assess the value of measuring menstrual blood loss before endometrial ablation. Starting in December 2013, West Africa was overwhelmed with the deadliest outbreak of Ebola virus known to date, resulting in more than 27,500 cases and 11,000 deaths.

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We describe here a 42-year-old woman who was admitted to hospital with a pedunculated mass in her left atrium. PAP and REG1A mRNA levels were measured in 265 surgically removed unifocal primary HCCs using reverse transcription-PCR.

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Self-association was dependent on protein and urea concentration and both influenced interactions of the protein with the chromatographic surface. The data extend at the level of immunoelectron microscopy previous observations, demonstrating for the first time the precise distribution and the differential expression of Nox4 in the morphologically distinct SMC types of healthy and diseased human aorta. In addition, the long-term outcomes of NADKD patients remain controversial. Girls with early pubertal timing had unfavorable BP levels at age 16 years, independent of BMI in childhood. These reactions are now used to selectively install particular modifications on proteins for many biological and therapeutic applications.

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High-precision measurement of electrical resistivity of nickel near the ferromagnetic phase transition at high pressure. The effects of cyclophosphamide and its uroprotective agents, mesna and hyperbaric oxygen, on urinary bladder motility in guinea pigs. Echocardiographic measurement of cardiac valvular thickness in healthy cows, cows with bacterial endocarditis, and cows with cardiorespiratory diseases. SBP caused by Bcc has been rarely reported in cirrhotic patients.

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Stretching is achieved by dispensing a droplet of sample solution containing DNA or denatured protein on a MgCl2-soaked mica surface. Forensic medicine has a role in documenting and evaluating these injuries and advising the judicial system in these cases.

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Since at the end of treatment period plasma IGF-I levels were similar in both groups it is likely that exogenous GH administration is responsible for the significant differences found. Because of the rapid increase in the number of procedures being performed, previously recognized complications have begun to recur. Caudal traction and tear of the subdural veins due to negative pressure caused by leakage of cerebrospinal fluid (CSF) following lumbar puncture (LP) is the mechanism.

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No sex difference occurs in hippocampus, food-storing, or memory for food caches in black-capped chickadees. The structure of the new benzylpiperazine was finally proved by two-dimensional NMR correlations and by GC-MS after synthesis of two of the possible isomers from commercially available starting materials. Central synaptic mechanisms underlie short-term olfactory habituation in Drosophila larvae. The induction of anesthesia with midazolam-ketamine was thus found to be a valuable method for allergic patients, because the incidence of histamine release, skin reactions and hemodynamic changes in allergic patients were similar to those in non-allergic patients induced by thiamylal and no significant changes were observed in the plasma histamine level after the administration of midazolam-ketamine in spite of the high level of basal plasma histamine. With respect to social and psychologic effects, performance of the procedure is extremely worthwhile because it not only provides complete limb preservation, but also has excellent potential for a favorable functional outcome.

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The results suggested that for these combinations, 3 times a day administration is as effective as 4 times a day. Experiment 2 tested a rat model of a possible solution to this problem. Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication. The tenuous vascular anatomy of the scaphoid, the inherent biomechanical instability of scaphoid fractures, and the difficulty of radiographic diagnosis are the culprits of nonunion. It remains unclear to what extent rehabilitation intensity or natural recovery effects changes in functional status for patients with hip fracture.

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To analyse the molecular epidemiology of drug-resistant tuberculosis (TB), and to characterise isoniazid (INH) and rifampicin (RMP) resistance conferring mutations in Finland during 1995-2004. Severe coronary artery spasm can be associated with hyperthyroidism. Atrial dilation and fibrosis are two of the core processes involved in atrial structural remodeling. The disease is associated with considerable morbidity and mortality.

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A ferric chloride-induced mouse carotid artery thrombosis model was used to determine the antithrombotic effects of fucoidan in vivo. Fluctuating asymmetry (FA) is thought to be an indicator of developmental stability and negatively related to male mating success in many animal taxa. The basic POD was purified by cation exchange and gel filtration chromatography.

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The role of physical activity in the prevention of osteoporosis in postmenopausal women-An update. The abnormal location of GAGs on these fibres may explain the apparent paradoxical weathered appearance of photodamaged skin despite increased GAGs. Inducible gene expression in mammalian cells and transgenic mice. The diagnosis of an asymptomatic pulmonary malignancy might be considered in the presence of ARF of unclear etiology in patients who undergo PCF surgery for removal of a brain tumor. It is our opinion that the transvaginal application of a laparoscopic bipolar cutting forceps can successfully assist vaginal hysterectomy in extremely obese endometrial cancer patients who cannot tolerate LAVH/BSO and lymphadenectomy and vaginal obesity limits visualization and exposure.

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For example, our results indicate that under certain conditions, many astronauts will misperceive a visual rotation axis to be centered in front of the head or even the torso. The history of RNA interference (RNAi) has unfolded rapidly since 1997 with a series of discoveries from plants, fungi, and animals. This paper draws on theories of ageing, body image and disfigurement, to explore the potential for relationships between oral health, body image and social interactions between institutionalised elders.

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Association of Lipid Profile and Uric Acid with Pre-eclampsia of Third Trimester in Nullipara Women. With an early and accurate diagnosis, genetic counseling and family planning can be offered in these difficult cases. This study demonstrated the presence of CA-MRSA and pvl positive strains in hospital settings and underlines the importance of using molecular typing to investigate the epidemiology of MRSA. Randomised controlled trials (RCTs) and quasi-RCTs comparing statins with placebo, no treatment or other statins in kidney transplant recipients.

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This 10-year review of Asian Americans focuses on factors that impede adequate psychiatric diagnosis and treatment. It has been known for some time that the double-helix is not a uniform structure but rather exhibits sequence-specific variations that, combined with base-specific intermolecular interactions, offer the possibility of numerous modes of protein-DNA recognition. Most strokes can be prevented through risk-factor modification and application of effective preventive therapies. Intestinal parasite and/or malaria co-infection is a health problem among pregnant women living around Gilgel Gibe dam area.

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The results show that UA inhibits tumor cell proliferation in a dose- and time-dependent manner. Finally, when TGF-beta was administered systemically to NOD mice after infection, the incidence of type 1 diabetes was reduced, thereby signifying a potential therapeutic role for TGF-beta. Photopolymerizable phosphate acrylates as comonomers in dental adhesives with or without triclosan monomer units. Mating disadvantages for rare females were found for sex-linked mutants (y and ct).

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Regulating knee joint position by combining electrical stimulation with a controllable friction brake. The capacity of Silver birch to phytoremediate TCE appears comparable to tree species that have been employed in field-scale TCE phytoremediation efforts, such as Populus spp. Among the fermented foods, soy sauces were rich in putrescine and histamine, while Japanese sake contained plenty of agmatine. Despite this net balance, our models predict substantial invasion and retreat of fire across large portions of the globe. Metformin inhibited pancreatic cancer initiation, suppressed chronic pancreatitis-induced tumorigenesis, and showed promising therapeutic effect in PDAC.

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The implementation of predictive genomic and molecular biomarkers will revolutionize urologic oncology and the clinical management of bladder cancer. The authors investigated this issue in 174 consecutive patients with bilateral NA-AION. Treating cancer patients by conventional chemotherapy to achieve prolonged survival still remains complicated. Support for the adverse effect of high income inequality on population health has come from studies that focus on larger areas, such as the US states, while studies at smaller geographical areas (eg, neighbourhoods) have found mixed results.

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Intraocular metastasis: comparison of clinical presentation with a known and unknown primary tumour. By extensive literature search, we have shown enough evidence for their deregulation in MDS. A uvsW deletion mutation was constructed to establish the null-allele phenotype, which is similar but not identical to the phenotype of the canonical uvsW mutation, and to demonstrate convincingly that the uvsW gene is nonessential (although uvsW mutations severely compromise phage production). We found brain-specific expression of the MAOA gene and different transcription levels in different dog breeds including Beagle, Sapsaree, and German shepherd, and also a robust association of the DNA methylation of the gene promoter with mRNA levels. Efficient molecular diagnostics of genetic predisposition to breast/ovarian cancer in Poland could be based on relatively simple tests disclosing some of the most frequent recurrent mutations of the BRCA1 gene.

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If this kind of therapy is unavailable at the time, it is advised that one of the conventional methods of controlling bleeding is used, introducing basic life support and transporting the patient to a specialist centre with adequate endoscopic facilities, radiological possibilities of endovascular intervention, and surgical treatment of liver transplantation. A comprehensive, model-based review of vaccine and repeat infection trials for filariasis. The results call for research into factors besides household food security in the search for determinants of child diet adequacy. Meanwhile, we provide data to show that the amino acid Ala-918 of H1 in the LRR domain has a close relationship with the resistant phenotype.

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Molecular characterization of variable heavy and light chain regions of five HIV type 1-specific human monoclonal antibodies. In the present study, we employed proteomics techniques to study protein changes of a poorly differentiated squamous carcinoma cell line-CNE2 of human NPCs cells induced by TPA.

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The budding yeast cohesin gene SCC1/MCD1/RHC21 genetically interacts with PKA, CDK and APC. Readmissions Have Declined, and Mortality Has Not Increased: The Importance of Evaluating Unintended Consequences.

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To reduce the huge labor-cost in the screening in traditional monoclonal antibody generation, We established a new system for monoclonal antibody generation integrating with protein array. The subcellular components of a single tafluprost-treated human hepatocyte were isolated and the single-cell metabolite profile was compared with those of traditional bulk hepatocyte analysis.

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A potential gravity-sensing role of vascular smooth muscle cell glycocalyx in altered gravitational stimulation. The process of range segmentation is divided into three steps: an initial range classification, a surface merging process, and a 3-D multiresolution range segmentation. Phenylephrine increased ventricular arrhythmias in affected dogs, with or without pretreatment with propranolol, but did not induce ventricular arrhythmias in unaffected dogs. Aberrant expression of microRNAs has been implicated in the pathophysiological processes underlying the progression of atherosclerosis. Neurenteric cysts in children: 16 consecutive cases and review of the literature.

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We describe how cpSPR43 adapts the universally conserved SRP system to posttranslational targeting and insertion of the LHCP family of membrane proteins. Stem loop IIa from U2 small nuclear (sn)RNA is required for the efficient association of the U2 small nuclear ribonuclear protein (snRNP) with the nascent spliceosome in yeast.

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The chronic emotionally disturbed patient: an efficient management model. Transformants of UAL26 containing cclEFGH showed a slight decrease in sensitivity to carnocyclin A, indicating that CclEFGH might also play a role in immunity. We report a case of a woman with a high-grade serous carcinoma of fallopian tube origin whose initial clinical presentation was palpable axillary lymphadenopathy. The reverse transcriptase-linked polymerase chain reaction (PCR) was used to identify the presence of cytokine mRNA within human pituitary adenomas. Five different tests were developed: wrist flexion, wrist extension, metacarpophalangeal joint flexion, thumb adduction and proximal and distal interphalangeal joint flexion.

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In recent years, multiple resonance techniques have been extensively used to examine details of the active-site structure, but basic continuous-wave (CW) EPR has not been re-evaluated in several decades. We sought to characterize the association between central line-associated bloodstream infection (CLABSI) or venous thrombus (VT) and PICC adjustment. Isolated systolic hypertension (ISH) is the most important risk factor for ischemic stroke.

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For this purpose, the American Association of Physicists in Medicine Task Group 223 on Dosimetry in Tomosynthesis Imaging has prepared this report that discusses dosimetry in breast imaging in general, and describes a methodology and provides the data necessary to estimate mean breast glandular dose from a tomosynthesis acquisition. In the case-control design, statistical efficiency is balanced with practical efficiency. Segmented words were classified into 6 categories and in each category of extracted words by target term and period were also tested. The world is confronted with fossil fuel depletion and environmental degradation. Cost analyses of extended prophylaxis with enoxaparin after hip arthroplasty.