Prilactone is a potassium sparing diuretic like eplerenone that competitively inhibits mineralocorticoid receptors in the distal convoluted tubule to promote sodium and water excretion and potassium retention. Prilactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered. It is indicated to treat a number of conditions including heart failure, deem, hyperaldosteronism, adrenal hyperplasia, hypertension, and nephrotic syndrome. Off label uses of Prilactone involving its antiandrogenic activity include hirsutism, female pattern hair loss, and adult acne vulgaris. Prilactone is also frequently used in medical gender transition. Prilactone was developed in 1957, marketed in 1959, and approved by the FDA on January 21, 1960.
Other names for this medication:
Spironolactone,
Aldactone,
Aldactazide,
Aldactazine,
Aldazida,
Aldazide,
Aldozone,
Alexan,
Alizar,
Carpiaton,
Espirone,
Espironolactona,
Expal,
Kespirona,
Lanx,
Letonal,
Osiren,
Osyrol,
Practon,
Prilactone,
Spiractin,
Spiresis,
Spirix,
Spiroctan,
Spirolang,
Spirolon,
Spiron,
Spirono,
Spironolacton,
Spironolactona,
Spironolakton,
Spironolattone,
Spirotone,
Verospiron,
Xenalon,
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Actisite,
Flomaxtra,
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Tumour proliferation measured by Ki-67 LI is related to tumour recurrence, stage progression, and is an independent predictor of DFS, PFS, and cancer specific OS in TaT1 bladder urothelial cell carcinoma. Accordingly, we sought to define an AngII-regulated proteome in primary human proximal tubular cells (PTEC) to identify potential AngII activity markers in the kidney. Various parameters like the radius of gyration, root mean square fluctuations, solvent accessibility were studied for evaluating the structural stability of the protein. A retrospective chart review of frontalis suspension patients over a 28-year norfloxacin tablets usp normax sacramento period was performed. With its close ties to yeast and the ease of genetic manipulation in this fungal species, A.
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