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Prograf (Tacrolimus)
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Tacrolimus

Prograf is the generic name for the macrolide immunosuppressant previously known by its experimental name FK506. Prograf was first discovered while screening for antibacterial activity of a multitude of compounds. This macrolide is produced by Streptomyces tsukabaensis, a bacterium found in the soil near Tsukuba, Japan. The mechanism of action of Prograf is closely related to that of cyclosporine. However, while Prograf binds tightly to the cellular protein named FKBP (FK506-binding protein) 12, cyclosporine binds cyclophilin. The target of either drug/intracellular receptor complex is a calcium-activated phosphatase called calcineurin, which is required for many functions in a variety of tissues: learning and memory, renal function, and immune responses. The selective sensitivity of immune function to these drugs has two reasons: 1. the low level of expression of calcineurin in lymphocytes relative to cells in other tissues; 2. an absolute requirement for calcineurin in immune activation. During antigen specific T-cell activation intracellular calcium is released and calcineurin is activated to dephosphorylate its target proteins including the transcription factor NFAT (nuclear factor of activated T cells). Upon dephosphorylation, NFAT translocates to the nucleus, where it binds its nuclear counterpart to form an active transcription factor inducing the production of several cytokines mandatory for initiating an immune response. Hence, calcineurin inhibitors interfere with antigen specific T-cell activation. Furthermore, Prograf affects the function of mast cells, basophile leucocytes and Langerhans cells. These characteristics explain the great interest to apply Prograf topically on inflamed skin, particularly since it was the first new topical immune suppressant since the introduction of steroids. The first successful use of topical Prograf in patients with atopic dermatitis was reported by Nakagawa et al. in 1994 and already 6 years later the U.S. Food and Drug Administration (FDA) approved Prograf ointment as a promising treatment for atopic dermatitis. Additionally, Prograf was investigated for a wide variety of inflammatory skin diseases beyond atopic dermatitis; particularly for conditions recalcitrant to other forms of therapy.

Other names for this medication:
Tacrolimus, Advagraf, Envarsus, Prograf,

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Characterization of revertants of unc-93(e1500) in Caenorhabditis elegans induced by N-ethyl-N-nitrosourea. However, only overexpressed Dcp1a but not GW182 was colocalized with DDX6, another component of P-bodies and suppressed protein translation. Acutely, cerebral blood flow (CBF) decreased immediately after BCCAO, producing a state of oligemic hypoperfusion. We conclude that phosphorylation of the middle region of Bir1 is required to bring Ndc10 to the spindle at anaphase, which is required for full spindle elongation. TLS-CHOP knockdown inhibited growth of MLS cells, and induced an anticancer cytokine, melanoma differentiation-associated gene 7 (MDA-7)/interleukin-24 (IL-24) expression.

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VN was highly expressed in placental basal plate of the early-onset severe preeclampsia group, which caused the imbalance of coagulation and fibrinolysis system and the pathogenesis of severe preeclampsia. Telehealth is being utilised as an alternative mode of service delivery to overcome such barriers. Despite considerable empirical and theoretical inquiry, the reason for the effectiveness of these novel speech patterns in suppressing stuttering is unknown. One-dimensional Heisenberg antiferromagnet of arbitrary spin in a strong magnetic field.

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Procyanidins, contained in many products abundant in human diet, exhibit high biological activity. Highspeed photography revealed considerable differences in leaflet motion between valves cycled at accelerated and physiological rates.

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Mineralization of the metre-long biosilica structures of glass sponges is templated on hydroxylated collagen. Phenotypic and functional studies of leukocytes in human endometrium and endometriosis. Old World Cutaneous Leishmaniasis (OWCL) is a preventable skin infection that leads to morbidity and social isolation. The results did not show statistically significant differences in patient satisfaction among the different occlusal schemes. Transurethral resection of prostate abscess: is it different from conventional transurethral resection for benign prostatic hyperplasia?

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Histone H2A variants are highly conserved proteins found ubiquitously in nature and thought to perform specialized functions in the cell. By virtue of their adjustable pore/cage sizes, high surface area, tunable functional sites, and rich host-guest chemistry, MOFs have emerged as promising candidates for both explosive sensing and desensitization. To compare the utility of procalcitonin (PCT) vs C-reactive protein (CRP) as indicators of late-onset neonatal sepsis in very low birth weight (VLBW) infants.

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To detect these changes, we have developed a novel method based on both spectrally and spatially resolved diffuse reflectance spectra. The experimental results showed that in the case of gelatin alone, the voltage drop increased slightly at high gelatin concentrations, due mainly to the steric effect and electrostatic interaction, but decreased at low gelatin concentrations due to the hydrophilicity.

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Actinomycin D abolished and dexamethasone concentration-dependently suppressed the TNF-alpha-induced enhancement of the des-Arg9-bradykinin and bradykinin responses. Upregulated expression levels of ADAM10 and EGFR and downregulated expression levels of E-cadherin in hepatocellular carcinomas. Anther cap retention times were determined for removed pollinaria and atmospheric vapour pressure deficit was recorded concurrently.

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The location management problem, which is to find the optimal network configurations of management under the mobile computing environment, is considered here as an optimization problem. In this study, we evaluated the diagnostic and prognostic significance of cerebrospinal fluid free light chains (CSF FLC) at the time of clinically isolated syndrome (CIS). Exploration of the breeding ground for increasing medical errors In addition, we also observed the decreased cell migration, cell proliferation, and DNA damage in UGT-transfected MCF-7 cells, suggesting a protective role of UGT against estrogen-induced mammary carcinogenesis.

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Task-shifting of orthopaedic surgery to non-physician clinicians in Malawi: effective and safe? Short-term corneal changes with gas-permeable contact lens wear in keratoconus subjects: a comparison of two fitting approaches.

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Five electronic databases were searched for relevant publications (SCOPUS, PsycINFO, MEDLINE, Emerald Insight, and JSTOR). To assess the prevalence of diabetes complications and the severity of diabetes in kindreds with NIDDM linked to the MODY3 locus (chromosome 12q) and to compare these parameters with data obtained in glucokinase (GCK)-deficient and other-MODY (unlinked to any of the three known loci) families, as well as with data from families with a late age of onset of NIDDM. A complete parotidectomy was carried out with an intraoperative notice of facial nerve infiltration requiring a second intervention for nerve and defect reconstruction.

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Metal bacteriochlorins which act as dual singlet oxygen and superoxide generators. Ethinylestradiol and testosterone have divergent effects on circulating IGF system components in adolescents with constitutional tall stature. Intraarterial infusion chemotherapy with lipiodol-CDDP suspension for hepatocellular carcinoma.

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Prophylaxis of dental caries and treatment of periodontal diseases with thermal waters This particular method of statistical analysis gave an opportunity to establish the major causes and risk factors of development of acute intoxications of chemical etiology in adult population of large industrial center. This phenomenon was seen predominantly for high risk breast cancer with low levels or no estrogen receptors in the primary tumor. Although the DTL fiber electrode has been in use in the ERG field for more than four decades, its composition was never clearly defined.

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Late regional density changes of the lung after radiotherapy for breast cancer. Since a single observation can be sensitive to local image characteristics, especially when the model is not accurate, we employ windowed multiple observations at each pixel to increase accuracy. Treatment decisions may be aided by consultation with a poison center and/or clinical toxicologist. Significant differences in striation density and length are found among the fossil taxa studied and the extant primates, suggesting that buccal microwear can be used to identify dietary differences among taxa.

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This model has not been used extensively for such experiments but allows a detailed evaluation of the quality of preservation. Heat or cold loads or their experimental equivalents, altered composition of inspired air or changes in blood gas composition, imbalances of body fluid control, and exposure to agents challenging the immune system were shown to elicit differential efferent sympathetic response patterns which often displayed a high degree of specificity. A roundabout path took me from a farm in Pennsylvania to a PhD under George Burr at Minnesota in 1939. Pancreatitis-associated protein (PAP) and regenerating protein 1 alpha (Reg1A) are up-regulated during the pancreas regeneration.

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Involvement of p53 in the repair of DNA double strand breaks: multifaceted Roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ). The authors describe the RI ICU Collaborative, funded by insurers and hospitals, and report on statewide central line-associated bloodstream infection (CLABSI) and ventilator-associated pneumonia (VAP) rates between 1 January 2006 and 30 June 2008.

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To quantify the initial deficit, change, and outcome in gait velocity during inpatient rehabilitation following stroke. Natural killer (NK) cells extend important immune resistance in vertebrates by lysing infected and tumor cells. Burch colposuspension does not provide any additional benefit to pelvic organ prolapse repair in patients with urinary incontinence: a randomized surgical trial. Malignant mesothelioma commonly arises from the pleura, but can also arise from the peritoneum, pericardium, and tunica vaginalis testis.

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Theory of the magnetic properties of isotropic ladder-type double chains with classical spins at the bunch-upright intersections: Application to Gd(III)-Cu(II) compounds. Researching this cellular interaction by describing the mechanisms of actions of various virulent factors may lead to new preventive therapies which will make the trauma patient less susceptible to S aureus infections. Categorical risk factors should be treated because of the lifetime increase in cardiovascular risk. We report here a case of advanced HCC with portal vein tumor thrombosis that was effectively treated with percutaneous ethanol injection (PEI), having previously enabled subsequent successive transarterial chemoembolization (TACE). Apoptosis Induced by 13-S-hydroxyoctadecadienoic acid in the Breast Cancer Cell Lines, MCF-7 and MDA-MB-231.

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Identification of specific secondary metabolites in adverse environment can also help us in understanding mechanisms of host tolerance against stress condition such as biological invasions, salt, drought, temperature. The Parental Bonding Instrument and Youth Self-Report were employed to assess the characteristics of these two population groups. Exposure of the lumbar spine to high-velocity flexion-extension triggers a significant increase in proinflammatory cytokines, indicating pronounced changes consistent with an acute inflammation.

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At term, the mother presented at the antenatal clinic with decreased fetal movements. Transgenic Tobacco Overexpressing Tea cDNA Encoding Dihydroflavonol 4-Reductase and Anthocyanidin Reductase Induces Early Flowering and Provides Biotic Stress Tolerance. Multipoint monitoring of a subject in an advanced driving simulator provides a practical example. The microbes colonized these surfaces within 25 days following the second stage surgery and placement of the healing abutment.

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