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Topigen (Topiramate)

Topigen is the brand name of Topigen, an anticonvulsant drug used to prevent seizures and reduce the frequency of migraines. While its exact mechanism of action is unknown, studies suggest Topigen might alter the production or action of neurotransmitters in the brain, suppressing the abnormal activity of the nerves in the brain that cause seizures or preventing the abnormal activity from spreading to other nerves. Other research has suggested that it might suppress the nerves directly, thereby making them less likely to fire. The Food and Drug Administration (FDA) approved Topigen to treat seizures in 1996.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Complete chloroplast genome sequences provide a valuable source of molecular markers for studies in molecular ecology and evolution of plants. However, the protocol and results may be of limited value in uncooperative animals.

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Thioredoxin reductase (TrxR) is crucially involved in redox homeostasis and essential for Plasmodium falciparum. In particular, this work presents a simple computational model, based on a 1D approximate solution of the Schockley-Ramo theorem, and its integration into the Geant4 application for tomographic emission (GATE) platform in order to perform accurately and, therefore, improve the simulations of pixellated detectors in different configurations with a simultaneous cathode and anode pixel readout. Vitamin A intervention: short-term effects of a single, oral, massive dose on iron metabolism.

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A synthetic peptide having a sequence identical to the putative second binding site on Galpha(i1) competes with binding of the second Gbetagamma subunit. Spinal MRI showed T2 hyperintensity from D9 to L1 suggestive of demyelination. The objective of this study was to compare a new biomarker index CD64 for neutrophils (iCD64n) with standard biomarkers, white blood cell (WBC) count, neutrophil/lymphocyte ratio (NLR), C-reactive protein (CRP) and procalcitonin (PCT) for the early detection of postoperative infection. Eutopic stromal and epithelial cells from endometriotic and normal patients were isolated by fluorescence-activated cell sorting for paired sibling RNA sequencing and microRNA microarray. However, the effect of COC on the reduction of asthma-related emergency department (ED) visits among older asthmatic patients is not clearly understood.

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Prospective Study of Pathogenesis of Atrophic Acne Scars and Role of Macular Erythema. Individuals with severe untreated GHD due to a homozygous GHRHR mutation and heterozygous carriers of the same mutation have smaller TV than normal subjects, suggesting that GH has a permissive role in the growth of the thyroid gland. These results should be considered in establishing rectosigmoid adenoma screening strategies.

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While the level of PCBs in milk per g lipid remained constant throughout lactation, vitamin E, as well as vitamin A and cholesterol, showed a marked decrease during lactation when expressed as quantity per unit lipid. Nevertheless, clinicopathological features had a low predictive value for prolonged treatment duration.

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We searched electronic databases, trial registers, and reference lists of published trial reports. We previously described that Id1Id3 double knockout (dKO) mouse embryos die at mid-gestation from multiple cardiac defects, but early lethality precluded the studies of the roles of Id in the postnatal heart. Furthermore, we examined if Ang II effect is mediated via AT1 receptor. Pre-treatment with trimetazidine increases sarcolemmal mechanical resistance in reoxygenated myocytes. Outcomes of antiretroviral treatment: a comparison between hospitals and health centers in Ethiopia.

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Differences among 5-HT3 receptor antagonists have been reported in pharmacological studies with regard to selectivity of receptor binding, potency, duration of action and dose-response curves. The 2008 Diversity Summit recognized the many advantages of increasing the number of neuropsychologists from ethnically diverse backgrounds. The trans-acting effect of activated src on neighboring cells can be blocked by inhibitors of src kinase or by siRNA-mediated knockdown of src expression, and it can be counteracted by forced up-regulation of connexin 43, via either gene transfer or proteasome inhibition. A university refractive surgery center retrospective chart review of 82 patients who elected to undergo surgical monovision with laser in situ keratomileusis (LASIK) between January 2000 and January 2003 was conducted. Later developments after day 4 are due to wound proliferation, collagen deposition, and re-epithelialization.

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A numerical estimation algorithm employing a sparsity constraint is used for object reconstruction. Characteristics of FTIR spectra of biogenic aragonite in mollusk shells Relative to younger adults (YA), older adults (OA) are less accurate at identifying fear, anger, and sadness, and more accurate at identifying disgust. The Coping Window: a contextual understanding of the methods women use to cope with battering.

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The in-vitro activity of trovafloxacin and nine other antimicrobials against 413 anaerobic bacteria. In conclusion, the combined PCR-DGGE approach relying on both total DNA extracts and culturable fractions proved its value for analyzing the effect of technological and environmental parameters on the diversity and dynamics of the microbiota in Gouda-type cheeses.

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Split times and perceived exertion were recorded at seven checkpoints. Mean transit time-derived PFR and PIMR can be assessed using a TPSG and adenosine or papaverine as hyperemic agents. Many forensic practitioners have reported unusual methods of suicide at their respective workplaces.

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The proliferative zone of flight animals was found to be significantly (P less than or equal to 0.01) larger than that of controls, while the reserve and hypertrophic/calcification zones were significantly reduced. The results revealed that the ethanol extracts of 30 plants out of the selected 58 possess significant antimicrobial activities. The size of the inserts in these clones ranged from 11 to 16 kb.

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The generation of functional human cardiomyocytes carries the potential of replacing damaged, malformed, or congenitally absent cardiac tissue as a definitive cure for cardiac disease. Telemedicine applications have been increasing due to the development of new computer science technologies and of more advanced telemedical devices. The proteins possibly encoded by this polycistronic gene cluster were all similar to the products of cytochrome c biogenesis genes from, amongst others, Rhodobacter capsulatus and Bradyrhizobium japonicum, not only in terms of amino acid sequence, but also in the overall hydropathy index of these proteins. These regulatory mechanisms are independent of Notch-mediated transcription and are executed by the extracellular domain of Notch. Then, the animals were sacrificed for determination of percentage of myocardial infarcion.

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Because most plants from temperate and cold climates experience a period of dormancy in winter, it seems likely that similar effects occur in other environments. Health professionals were considered to be important sources of information and they should therefore use up-to-date information concerning this topic. In fact, despite significant advances, several key points on the Mia40 pathway remain to clarify namely on the molecular mechanism trough which substrate oxidative folding is catalyzed. Markers of left ventricular dysfunction were better predictors of a poor prognosis than markers of ischemia.

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Metabolism of platinum ( 14 C)ethylenediamine dichloride in the rat. The anteroposterior position of the hyoid bone was more forward in subjects with short face syndrome. Hereditary hemochromatosis in siblings: diagnosis by genotyping.

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Peripheral arterial disease, as detected by a reduced ankle-to-arm blood pressure index (AAI), has been shown to predict future cardiac events. Finally, as shown with real-time PCR, galanin and its receptors were expressed at very high levels in human pheochromocytoma tissues as compared with normal adrenal medulla. For UC patients the linear relationship between dietary iron intakes and the scores from the disease specific inflammatory bowel disease questionnaire (IBDQ) was also considered. We analyzed the cytopathological findings of 15 cases of endobronchial ultrasound guided aspiration and a case of bronchial washing.

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Superior vena cava-right pulmonary artery anastomosis (Glenn operation). Inhalation of hydrogen cyanide also exhibited direct effect on the pulmonary cells as evidenced by decreased compliance.

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Twenty-five percent of the low-dose CT images in this study demonstrated abnormalities. Postmortem MRI and autopsy are complementary, and each may disclose abnormalities missed by the other.

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Paraplegia is not a diagnosis: Spinal tuberculosis deserves a place on the clinical radar screen: Awakening call to clinicians. gingivalis to exploit fast recycling pathways promoting further bacterial penetration of gingival tissues.

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We searched the electronic database PubMed for preclinical as well as clinical controlled studies pertaining to metabolomics analyses of maternal parameters and their influence on fetal growth. Soft contact lenses are still responsible for the majority of serious amebic corneal complications.

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In order to support implementation, staff assigned as IFs as well as stakeholders like managers at all levels of an organisation should be engaged in realising commitment, negotiating conditions, and keeping momentum going. Here we describe the ChIP-reChIP assay that represents a direct strategy to determine the in vivo colocalization of proteins interacting or in close contact in a chromatinized template on the basis of double and independent rounds of immunoprecipitations with high-quality ChIP grade antibodies. Both simulation and practical application demonstrate that the proposed method can be effective in practice. The purpose of this study was to compare the potential risk of needle tract seeding of breast cancer from ultrasonographically guided needle biopsies that were performed with a directional vacuum-assisted device and an automated core needle gun. The measurement properties of the Roland-Morris Questionnaire have been shown to be better than or equal to competing measures.

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Post-partum depression and infant growth in a South African peri-urban settlement. We examined whether maternal smoking and use of nicotine substitutes during the first 12 weeks of pregnancy increased the prevalence of congenital malformations in general and of certain congenital malformations in particular. Six required surgical intervention on the affected valves, and 2 required multiple valve surgeries.

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This method has beer used to determine the three elements in grain and the results are satisfactory. However, no experimental study has clearly demonstrated any preventive or therapeutic inhibition of an allergen-specific IgE response. Therapeutic options during angiography depend on the cause of ischemia and include administering intra-arterial vasodilators and/or thrombolytic agents and angioplasty with or without stent placement. No relationship was seen between breast cancer and HCMV in this study.

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For the first time a physiologically based pharmacokinetic (PBPK) model has been developed in juvenile and adult humans and nonhuman primates to quantitatively evaluate species- and age-dependent enantiomer specific pharmacokinetics of MPH and its primary metabolite ritalinic acid. Various views on the formation of the spatial structure of proteins Repeated dose (14 days), subchronic (13 wk) and chronic (2 yr) studies were carried out in succession to evaluate the toxic and carcinogenic effects of diglycidyl resorcinol ether (DGRE), a liquid spray epoxy resin, in F344/N rats and B6C3F1 mice. This simple, linear reasoning was frequently based on cytokines that were defined using endotoxin models of sepsis.

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According to these results, it is possible to understand that these signal molecules are found in the infection caused by A. We aimed at evaluating the effect of hemodialysis with polysulfone membranes on selenium status. A comparison of vagotomy plus pyloroplasty with Billroth I gastrectomy in the treatment of gastric ulcer. Ten patients with hyperparathyroidism and two normal subjects underwent parathyroid scintigraphy with both 99Tcm-tetrofosmin and 201TI.

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This case highlights the need to consider a pericaecal hernia as a differential cause of right iliac fossa peritonism, and an indication for radiological imaging such as CT scan when the history is atypical for acute appendicitis. The WM structural networks were constructed by utilizing diffusion tensor tractography and calculated topological properties of the networks using a graph theoretical method. Furthermore, among the eight populations sampled from apple in different geographic regions throughout Switzerland, AMOVA and pairwise FST analysis revealed significant population genetic differentiation even between populations collected from orchards 10 km apart. The aim of the present study was to assess the impact of fortified food (FF) consumption on overall dietary quality in Irish adults. Chemical labeling studies on the AChR have identified tryptophan residues on the gamma (gammaTrp-55) and delta (deltaTrp-57) subunits that interact with curare.

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Taken together, these results illustrated that H2 S function as an indispensable positive regulator participated in OsSE5-promoted ammonium tolerance, in which nitrogen metabolism was facilitated. Six patients met our selection criteria from the hospital records, and 4 case reports from the literature search were also included. Chemostat Culture for Yeast Physiology and Experimental Evolution.

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This cross-sectional survey was performed in 504 daily smokers, who were selected from data records of Global Adult Tobacco Survey (GATS) between February and April, 2009. The ultimate consequence of quantum many-body physics is that even the air we breathe is governed by strictly unitary time evolution.

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These novel superactive mouse and human leptin antagonists (D23L/L39A/D40A/F41A), termed SMLA and SHLA, respectively, exhibited over 60-fold increased binding to leptin receptor and 14-fold higher antagonistic activity in vitro relative to the L39A/D40A/F41A mutants. Data from the FIM, collected on inpatient admission, was fitted to the Rasch model. The main aetiological agent of the condition was identified as Stenotrophomonas maltophilia. The crystal phase, morphology, surface state, and photochemical properties of the BSO materials are precisely tuned to fabricate two kinds of bismuth silicate heterostructures: rod-like Bi2SiO5/Bi12SiO20 and flower-like Bi2SiO5/Bi4Si3O12 heterostructures.

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According to our experience as well as according to the literature, it is recommended to use at least three reference genes in order to obtain reliable results. Aurora Kinase A (AURKA) is often overexpressed in neuroblastoma (NB) with poor outcome. In this study, we utilize carcinoma cells depleted of ErbB2, but not other ErbB receptor members, to specifically examine the role of ErbB2 in carcinoma cell migration and invasion. A 13-year-old boy presented with a 2 weeks history of tearfulness, childish behaviour, separation anxiety, hypersomnia, hyperphagia and sexual disinhibition following a brief episode of fever.

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After PQ poisoning, the SD rats were randomly divided into the PQ control group (treated with normal saline), the sodium bicarbonate (SB) treatment group, and the sucralfate (LTL) treatment group. Multiple genotype-phenotype correlations outside the SRO are explored, including further validation of the deletion of WTIP as a candidate for male hypospadias observed in this syndrome. 630 bp) of the 18S nuclear ribosomal RNA gene (rDNA) in the Japanese Eothenomys voles, E. When the association between CMV antibodies and atherosclerosis was examined in stratified analyses, a significant association was restricted to individuals with high levels of lipoprotein(a) and fibrinogen. Among the wide variety of design options for a tax credit, policy and political analysis does not reveal an obvious choice, but a tax credit based on a percentage of spending may have a slight advantage.

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Fifty-nine patients treated with definitive radiotherapy for early glottic cancer between 2003 and 2011 were enrolled. Central cardiovascular adaptations were indicated as the primary source of these beneficial alterations in exercise responses. Predictors of discontinuation of tumor necrosis factor inhibitors in patients with rheumatoid arthritis. It is well described in children and adults with diabetes and organ transplantation, but has not been previously reported in healthy adults. The morphological characteristics together with clinical and radiologic findings confirmed the tumor to be a central odontogenic fibroma (COF) with secondary gingival involvement.

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Groups of females underwent sham surgery, ovariectomy or ovariectomy plus estrogen for 1 or 2 weeks. The study sample was 455 MDD patients aged between 18 and 55 years.

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Fourier transform infrared (FTIR) spectroscopy is the most common spectroscopic technique used for study of protein structure. Safety and efficacy of repeated ketamine infusions were attained without medication-free state in patients with TRD.

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A two-arm randomized study was conducted to test the hypothesis. Liquid-based cytology samples were analyzed centrally for HPV genotype and for cytologic features.

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Trituration of base substances, commonly to the 3cH level, is the cornerstone of the homeopathic pharmaceutical process or insoluble solutions. There no significant differences between the alcoholic and nonalcoholic bipolar patients in family history of alcoholism or affective disorders, suggesting that bipolar illness with alcoholism is not explicable by a family history of alcoholism and that the alcoholism seen in bipolar illness is dissimilar to alcoholism as a primary disorder. Recurrent respiratory papillomatosis is an uncommon clinical disorder of the respiratory epithelium caused by HPV. This may be explained by interaction of melatonin and aceten actions. Accuracy and pladex tablets reproducibility of a novel dynamic volume flow measurement method.

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The results of this study demonstrate that the plant-produced PfGAP50 is functional regarding the presentation of inhibitory epitopes and could be considered as component of a transmission-blocking malaria vaccine formulation. Every effort should be made to avoid situations stimulating new heterotopic ossification due to its substantial effect on the quality of life of FOP patients. Increased size of eukaryotic genomes necessitated the use of lansor tablet ne kadar multiple origins of DNA replication, and presumably selected for their efficient spacing to ensure rapid DNA replication.

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A 46-year-old patient with chronic active type nervix medication B hepatitis is reported in whom superinfection with delta virus developed. Satisfaction and sense of well being among Medicaid ICF/MR and HCBS recipients in six states.

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Two cysteine residues (C-265 and C-318) in the putative hydrophilic regions of sarcosine oxidase were substituted by lansox 30 mg gastrite aigue using site-directed mutagenesis. At each step, the most similar pair of regions is determined (minimum cost RAG edge), the regions are merged and the RAG is updated. Methods for the measurement of the zinc content of blood components (plasma, erythrocytes, platelets, mononuclear leukocytes, and polymorphonuclear neutrophils) as indicators of the zinc status of animals have been reviewed and evaluated.

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Monitoring of SjO2 in severe head injury provides an estimate of cerebral oxygen supply and may improve the buy dentomycin assessment of therapeutic measures in these patients. Such rate constants also give information about the relative energetics of the two binding processes.

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Should habitat trading be based on mitigation ratios derived from landscape indices? Isoxazolinylacetamides bearing a phosphoramidate group alpha- to the carboxylate moiety (3) were prepared clopidogrel ttp symptoms of ovarian and evaluated for in vitro antiplatelet efficacy. The gradient was less clear for patients with colorectal carcinoma, whereas no socioeconomic variation in comorbidity was found for patients with carcinomas of the prostate or stomach. Thrombin, TNF-alpha, and LPS exert overlapping but nonidentical effects on gene expression in endothelial cells and vascular smooth muscle cells. Herein, we report an unusual case of a patient with PBC and RA, and discuss the association between these two diseases.

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Isolated extramedullary adnexal relapse of acute lymphoblastic leukemia: a case report For example, aldehydes comprise a significant fraction of atmospheric organics and are likely to accumulate at aqueous surfaces. A simple fibril and lectin model for cyst walls of Entamoeba and perhaps Giardia. This allows the ribavirin side effects vision express method to be extended to more proximal and distal fractures than in the traditional method which is applicable only to the middle third.

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The purified UBP6 behaved as a 58-kDa under both nondenaturing and denaturing conditions, indicating that the enzyme comprises a single polypeptide. Antimicrobials: Modified sugar compound cotrim forte ratiopharm 96067 can clear intestinal colonization by UPEC.

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Each regimen selected for polymorphisms associated with decreased treatment response. Establishment of animal models with orthotopic panklav forte sirup doziranje lantusa hepatocellular carcinoma. Structure-reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase.

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Discovery of a novel class of 1,3-dioxane-2-carboxylic acid derivatives as subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists. Corrigendum: Spongy Gels by a Top-Down Approach from Polymer Fibrous Sponges. Thoracic radiography revealed a round soft tissue opacity near the aortic arch and below the second thoracic vertebra on a lateral view. Our study indicates that bone marrow cells accelerate the healing of wounds at least in part through their differentiation into levofloxacin side effects help wound myofibroblasts. Moreover, the direction of the present force is found to be the opposite of the prediction of the standard spin-transfer torque, resulting in the domain wall motion along the current direction.

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The enterocyte (epithelial cell) secretion hypothesis rapidly displaced all other alternatives, such as vasodilatation coupled with enhanced paracellular permeability. The potential role that protein kinase inhibitors play spironolactone 25 mg 500 count bottled is discussed on the basis of a new understanding of the mechanisms modulating phosphoregulated pathways. Proceedings of the national burn surge strategy meeting, Atlanta, Georgia, March, 2012. The aim of our research was to examine the significant barriers encountered in recruiting adults with ID to participate in research. The findings indicate that the recall and perception of the more overt negative messages increase with exposure and that receptiveness to the subtle and less remembered positive messages increases with levels of program connectedness.

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