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Topina (Topiramate)

Topina is a sulfamate-substituted monosaccharide with anticonvulsant property. Although the mechanism of action has not been fully elucidated, Topina antagonizes kainate/AMPA subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (GABA) activity and thereby attenuating GABAnergic inhibitory transmission.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Dislocation core-core interaction and Peierls stress in a model hexagonal lattice. In neonatal medicine, there is a technologic revolution in progress. Flow cytometric analysis showed that IL1beta, tumour necrosis factor alpha, and IL18 up regulated IL18Ralpha expression levels. Pineal denervation and/or adrenal demedullation neither completely eliminated NA from blood nor prevented cocaine-induced stimulation of melatonin synthesis in these light-primed animals.

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Multivariate and univariate analyses revealed that tutoring and imitation were manifested more in asymmetrical dyads, while cooperation and parallel activity were more frequent in symmetrical dyads. We found no evidence of a cost to females of investment in horns. Magnetic resonance imaging showed numerous round lesions in the brain which looked nodular after contrast-medium injection. Characterizing the temporal patterns of avian influenza virus introduction into Japan by migratory birds. The emerging area of lineage modulation within the adult pancreas is of particular interest, and this review summarizes recent findings that exemplify how lessons learned from development are being applied to reveal the potential of fully differentiated cells to change fate.

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On the other hand, a quantitative agreement with respect to experiments, both in the magnitude and direction of the magnetic anisotropy, can be recovered by using the wavefunction-based approach which is able to fully describe the multiplet physics. In vivo, we observed that Zcchc6 is expressed in mouse and human primary macrophages. Human macular OPs consist of 3 to 4 wavelets (mean peak interval, approximately 6.5 msec).

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Spread of stimulating current in the cortical grey matter of rat visual cortex studied on a new in vitro slice preparation. Recent advances in genome analysis have provided important insights into the genetic architecture of infectious and inflammatory diseases. Induction and rejoining of breaks in the deoxyribonucleic acid of human cells irradiated at various phases of the cell cycle. Histological examination showed that the saphenous vein was fragile.

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The ability of autophagy to contribute to the maintenance of lipo-homeostasis becomes particularly relevant in the context of genetic lysosomal storage disorders where perturbations of autophagic flux have been suggested to contribute to the disease aetiology. In the present study, we examined the postreceptor effect of antidepressant treatment on the protein and mRNA levels of stimulatory and inhibitory C protein alpha-subunits (G alpha s and G alpha i) and beta-subunits in rats infused continuously with various antidepressants for 21 days. Profound alterations in both biochemical and immunological conditions appeared after the starvation period.

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Demographic inference supports a model in which the ancestral A. Animal development and lifetime potential exploit a balance between the stability and plasticity of cellular identity. Binge-drinking is common in underage alcohol users, yet we know little regarding the biopsychological impact of binge-drinking during early periods of development.

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Shoot regeneration of mesophyll protoplasts transformed by Agrobacterium tumefaciens, not achievable with untransformed protoplasts. The reactivating and therapeutic potency of both newly developed oximes does not prevail over the effectiveness of currently available obidoxime and trimedoxime and, therefore, they are not suitable for their replacement of commonly used oximes for the treatment of acute tabun poisoning.

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Clarifying the range of social-cognitive processes subserving human teaching. Of the potential extra-articular sites implicated in disease initiation, mucosal tissues have garnered increasing attention.

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Exploring the potential of gastro retentive dosage form in delivery of ellagic acid and aloe vera gel powder for treatment of gastric ulcers. These TEELs are approximations to ERPGs to be used until peer-reviewed toxicology-based ERPGs, AEGL or equivalents can be developed.

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While the cytologic features of silicone lymphadenopathy are diagnostic in the appropriate clinical setting, excision of the lymph node may be advisable to exclude a concomitant malignant neoplasm. Oil, Gas and Conflict: A Mathematical Model for the Resource Curse.

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The necessity of bibliometric markers cannot be called into question however the most widely employed of these, the journal impact factor has come under increased scrutiny of late. Easily misdiagnosed delayed metastatic intraspinal extradural melanoma of the lumbar spine: A case report and review of the literature.

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MR of uncommon congenital and vascular lesions of the intracranial visual pathways. parapertussis can inhibit adherence of the bacteria to bronchial epithelial cells, irrespective whether these structures play a role in adherence of the bacteria to these cells.

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Unravelling autoimmune pathogenesis by screening random peptide libraries with human sera. We queried the data from the International Multicenter National Parkinson Foundation Quality Improvement study. PP2A inhibition occurs in many cancers and is considered a tumour suppressor. While there is ample evidence for the relevance of complex odor blends in ecological interactions and for interactions of chemicals in both peripheral and central neuronal processing, a fine-scale analysis of rules governing the innate behavioral responses of Drosophila melanogaster towards odor mixtures is lacking.

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The antiserum may be very specific for domains of the Lom OMP molecule that have not been highly conserved during evolution or possibly these domains are not accessible to the antiserum in other insects. The Stoma Quality of Life Scale demonstrates reasonable psychometric properties for measuring quality of life in patients with stomas. Work over the past two decades has established that the PCM in adult tissue is defined biochemically by several molecular components, including type VI collagen and perlecan.

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Limitations of the study and suggestions for future research are discussed. Blocking 1800 MHz mobile phone radiation-induced reactive oxygen species production and DNA damage in lens epithelial cells by noise magnetic fields The introduced approach is illustrated on the problem of a noninvasive unsupervised brain signal classification. Absenteeism was only higher in T2DM with complications, but there were no differences among groups either in the duration or in the cost of such absenteeism.

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Thus, we concluded that taurine depletion did not account for the central retinal lesion in the white Bengal tiger. Adenosine (ADO)-induced hypotension during diethyl ether anesthesia has been shown to increase skeletal muscle oxygenation. In contrast to what one might expect from its nature as a group V element, we find that As does not occupy substitutional O sites but in its large majority substitutional Zn sites. A two-way soft resolution method will fail when applied to a simultaneous equilibria system due to rank deficiency in its concentration profiles.

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Effects of Resveratrol and Other Polyphenols on Sirt1: Relevance to Brain Function During Aging. Conversely, strategies and tactics implementing existing technologies may result in more benefit in the end. Ease of the procedure, safety, extent of dilatation, and girth of prosthesis implanted. Inhibition of rho-kinase by fasudil suppresses formation and progression of experimental abdominal aortic aneurysms.

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This paper highlights the burden of cancer in Nigeria and the ethical challenges of clinical management of cancer patients, using a case study. Vertical circularly polarized ELF magnetic fields and induced electric fields in culture media. To assist administrative nurses who may some day be involved in a withdrawal of nursing services, this manuscript contains an account of the pre-strike preparations, putting these plans into action during the strike, and the immediate post-strike period at the Plains Health Centre, a tertiary care facility in Regina, Saskatchewan.

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Mutations in the presenilin 1 (PS1) gene are responsible for the early onset of familial Alzheimer disease (FAD). Such calibrated physical models provide new ways to assess seismic hazards and forecast seismicity response to perturbations of natural or anthropogenic origins. to present a case of a rare disease of the colon with discussion on diagnostic and therapeutic principles. This procedure now is used widely for patients at high and intermediate risk for surgical aortic valve replacement. The SMSSI provides a standardized platform on which quantification of subjective reports can be based.

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We use a microfluidic chip for the mesophase formulation and in situ SAXS data collection. One of the most pressing environmental concerns of our age is the escalating level of atmospheric CO2 . Periodontal and Restorative Treatment of Gingival Recession Associated with Non-Carious Cervical Lesions: Case Study. This analysis indicates a single catalytic site in tyrosinase for all enzymatic activities. Health legislation, Commonwealth and State, in relation to medical practice.

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The induction of labour using small transbuccal doses of syntocinon. Olig2 overexpression accelerates the differentiation of mouse embryonic stem cells into oligodendrocyte progenitor cells in vitro. While the cause remains unclear, our findings might be explained by increased attention by patients and physicians. ABCG2 is a urate transporter, and the Q141K and Q126X variants of ABCG2 have been associated with a risk of developing gout, though previous studies of these associations have been inconsistent. With this representation, the opening and closing operations are accomplished by a local matrix operation rather than cascade operation.

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Importantly, pyQms performs very well to accurately quantify partially labeled proteomes in large scale and high throughput, the most challenging task for a quantification algorithm. Lactobacillus gasseri SBT2055 (LG2055) is one of the probiotic lactic acid bacteria. Only a small fraction of the secreted protein was incorporated into the pericellular matrix.

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Nineteen independent studies were identified, mostly comprised of middle aged or older adults. Metastasis of EOC occurs primarily through the transcoelomic route whereby exfoliated tumor cells disseminate within the abdominal cavity, particularly to the omentum. SMILES-based quantitative structure-property relationships for half-wave potential of N-benzylsalicylthioamides. This study aimed to assess the oral health status and awareness among the tuberculosis patients in an Indian population. This review briefly summarizes what is known about the inflammatory nature of atherosclerosis and how long-term aerobic exercise can reduce the atherogenic activity of endothelial cells, blood mononuclear cells, and adipose tissue.

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The chemical structure and morphology of the synthesized polyaspartamide-g-C18/DOPA nanoaggregates were analyzed using 1H-nuclear magnetic resonance spectroscopy (1H NMR), dynamic light scattering (DLS), and transmission electron microscope (TEM). Potassium permanganate oxidation of phenanthrene and pyrene in contaminated soils. For those who change, the proof of their success will be science that is read, understood, and remembered.

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Downregulation of Hsp27 by a siRNA treatment promoted apoptosis in HREC. Critical goals to overcome poverty and accelerate human development. Some microbeads penetrated to the substratum within the 24-h bead addition period. We show here that low transfer efficiencies between primary producers and consumers during cyanobacteria bloom conditions are related to low relative eicosapentaenoic acid (20:5omega3) content of the primary producer community. The ACE gene shows an I/D polymorphism, which correlates with ACE concentrations.

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A recombinant vaccinia virus expressing canine interferon (IFN)-beta was constructed (vv/cIFN-beta). Athens Eye Hospital Ocular Oncology multidisciplinary team providing combined treatments for patients with choroidal melanoma: 3 years results. The results suggest that these individuals are better adapted to high altitude and that, at altitude, they have a greater physical capacity than Han (ethnic Chinese) lowland newcomers.

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This HF stem cell-targeted gene transfer and reconstitution system provides reliable gene-function analysis and gene therapy. Eighty healthy giant-ear white rabbits were randomly divided into 4 groups, a blank group, a model group, an electroacupuncture (EA) group and an immunoglobulin group, 20 rabbits in each group. The purpose of this study was to assess lower extremity dynamic muscle function and muscle anatomy in OI type I. Common findings show the difficulty of introducing large-scale interventions, and that effective leadership and clinical champions, adequate financial and educational resources, and dedicated promotional activities appear to be common factors in successful system-wide change.The protocol has been registered in the international prospective register of systematic reviews, PROSPERO (Registration No.

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He exhibited bilateral conjunctival xerosis with complete corneal melt in the right eye and a large corneal epithelial defect with underlying anterior chamber inflammation in the left eye. In addition, the results of this work provide insight on some general guidelines with respect to the method combination best suited for deriving descriptors for environmentally relevant compounds. Cultural Evolutionary Perspectives on Creativity and Human Innovation. Intestinal epithelial cells (IECs) are constantly exposed to commensal flora and pathogen challenges. To preserve fertility, rescue cryopreservation of ovarian tissue was carried out under extreme conditions (without adopting the standard published protocol, not yet available at our centre).

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Temporal relaxation of nonequilibrium in Y-Ba-Cu-O measured from transient photoimpedance response. Towards an Integrated View of Early Molecular Changes Underlying Vulnerability to Social Stress in Psychosis.

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To examine the extent of physical health impairment among a community sample of methamphetamine users in comparison with the general population, and factors associated with impairment among this group. The open-sea dives were carried out with an average speed of descent of 3.95 feet per second and an average rate of ascent of 3.50 feet per second.

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During the post 20 years many studies exposed the clinical correlates of this antibody system (now called anti U1RNP). Together, these data demonstrate that active MCM2-7 repression is a physiologically important mechanism for RS-induced cell cycle arrest and genome maintenance on an organismal level. Neotrombicula kenyaensis Goff and Neotrombicula centrafricana Goff are described as new from specimens collected from the primates Galago senegalensis E.

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Recently, we developed an automated multiplexed-tandem (MT)-PCR platform for the diagnosis and identification patent infections with key genera/species of gastrointestinal nematodes of sheep and validated this approach in detailed experiments carried out in Australia. Immunohistochemically, the tumour cells expressed alpha-inhibin, while epithelial membrane antigen was not detected, indicating a sex cord-stromal origin of the tumour.

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The upregulation of EGFR and 8-OHdG protein levels in KC epithelium compared with FECD controls implicates oxidative stress in KC corneas. Insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4), a consistent inhibitor of IGF action, is subject to proteolytic cleavage by the IGF-II-dependent IGFBP-4 protease.

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Exposure to high air pollutant concentration might be associated with reduced pulmonary function in adult males. Therefore, this option warrants emphasis with regard to its relative merit compared to total cystectomy. Although no significant differences in pre-treatment rCBF were observed between responders and nonresponders to BT, the post-treatment rCBF values in the left medial prefrontal cortex (Brodmann area 10) and bilateral middle frontal gyri (Brodmann area 10) were significantly lower in the responders than in the nonresponders. Here, we provide a detailed protocol for the LASH assay to detect a specific miRNA, as a model for the detection and quantification of extracellular miRNAs.

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All compounds are orally bioavailable and have proved to be highly potent and selective inhibitors of CCR5 using (R5) HIV-1 replication in cell cultures. Syntheses of vanadyl and zinc(II) complexes of 1-hydroxy-4,5,6-substituted 2(1H)-pyrimidinones and their insulin-mimetic activities. The gold cluster played an important role in both immobilizing antigen and accelerating electron transfer. Preferences for Professional Assistance for Distress in a Diverse Sample of Older Adults.

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Determinants of intention to quit smoking among Dutch employees: the influence of the social environment. To compare the average glandular dose (AGD) and diagnostic performance of mediolateral oblique (MLO) digital breast tomosynthesis (DBT) plus cranio-caudal (CC) digital mammography (DM) with two-view DM, and to evaluate the correlation of AGD with breast thickness and density. At 7 weeks gestation, one challenge group was given an intranasal dose of cell culture medium, whilst the other two were given intranasal doses of either BVDV-1 or BVDV-2, using the same inocula as for the immunisations. The extracts from every sample were applied on the MDPC-23 cells. The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal tenofovir df emtricitabine and efavirenz vs to the second calcium binding domain of its alpha subunit.

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Testosterone-guided ADT reduces exposure to LHRH agonists, with reduction in cost and improvement in some symptoms from ADT. Using narrative methods, 12 student nurses with dyslexia from two higher education institutions in the Republic of Ireland were interviewed during the period February-July 2012. administrations of Ad-IL-10 (one 10 x 10(9) and two 5 x 10(9) particles of adenoviral construct, respectively), as judged by reduced clinical scores and decreased leukocyte infiltration in the anterior chamber and confirmed by histological examinations, relative to control animals. A novel approach for quantitative evaluation of the physicochemical interactions between rough membrane surface augmentin es-600 dosage chart and sludge foulants in a submerged membrane bioreactor.

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