Vardenafil is another selective PDE-5 inhibitor that is approved for the treatment of erectile dysfunction. It is effective in a broad spectrum of underlying conditions of patients. Vardenafil potentiates the increase in intracellular cGMP in the corpora cavernosa in response to sexual stimuli, resulting in enhanced and prolonged erections. The overall tolerability and safety profile is acceptable. The major side effects observed by some patients are headache, flushing, rhinitis, and dyspepsia [96-107]. Vardenafil is considered five to 10 times more potent than sildenafil. Structurally, Vardenafil is very similar to sildenafil (38.3.1) and differs in that the pyrazolo-pyrimidine heterocycle is replaced by an isosteric imidazo-triazine core.
Other names for this medication:
Vardenafil,
Levitra,
Staxyn,
Vilitra,
Vivanza,
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